Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
Department of Anaesthesiology, Fudan University Shanghai Cancer Center, No.270 Dong-an Road, Shanghai 200032, P.R. China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China
Br J Anaesth. 2014 Jul;113 Suppl 1:i49-55. doi: 10.1093/bja/aeu148. Epub 2014 Jun 25.
Serum vascular endothelial growth factor-C (VEGF-C), transforming growth factor-β (TGF-β), and interleukin (IL)-6 promote angiogenesis and metastases in colon cancer. We hypothesized that patients who received propofol-epidural anaesthesia (PEA) would exhibit decreases in VEGF-C, TGF-β, and IL-6 and an increase in IL-10 compared with patients who received general anaesthesia (GA).
Colon cancer surgery patients were randomly assigned to the PEA (n=20) or GA (n=20) group. Serum VEGF-C, TGF-β, IL-6, and IL-10 levels before surgery and 24 h after surgery were measured.
Patients who received PEA showed decreases in VEGF-C [526 (261) vs 834 (304) pg ml(-1), P=0.001], TGF-β (P=0.027), and IL-6 (P=0.007) and an increase in IL-10 (P=0.001) 24 h after surgery compared with patients subjected to GA. The visual analogue scale scores at rest and during coughing at 2 and 24 h after operation were significantly lower in PEA patients (P<0.05).
PEA reduces serum concentrations of factors associated with angiogenesis during colon cancer surgery.
ChiCTR-TRC-13003146 (www.chictr.org).
血清血管内皮生长因子-C（VEGF-C）、转化生长因子-β（TGF-β）和白细胞介素-6（IL-6）促进结肠癌的血管生成和转移。我们假设与全身麻醉（GA）相比，接受异丙酚硬膜外麻醉（PEA）的患者 VEGF-C、TGF-β 和 IL-6 水平降低，IL-10 水平升高。
将结肠癌手术患者随机分为 PEA（n=20）或 GA（n=20）组。分别于术前和术后 24 h 测量血清 VEGF-C、TGF-β、IL-6 和 IL-10 水平。
与 GA 组相比，PEA 组患者术后 24 h 时 VEGF-C[526（261）比 834（304）pg/ml，P=0.001]、TGF-β（P=0.027）和 IL-6（P=0.007）水平降低，IL-10 水平升高（P=0.001）。术后 2、24 h 时，PEA 组患者静息和咳嗽时视觉模拟评分均显著低于 GA 组（P<0.05）。
PEA 降低结肠癌手术期间与血管生成相关的血清因子浓度。
ChiCTR-TRC-13003146（www.chictr.org）。
