Yadav Kiran, Aggarwal Shalini, Verma Kamlesh
KEM Medical College, H/43, MSHS, Ambekar Nagar, GD Ambekar Marg, Parel, Mumbai, 400012 India.
Maharaja Agarasen Hospital, Punjabi Bagh, Delhi, India.
J Obstet Gynaecol India. 2014 Jun;64(3):169-74. doi: 10.1007/s13224-013-0490-3. Epub 2013 Dec 17.
A variety of biological, biochemical, and biophysical markers implicated in the pathophysiology of pre-eclampsia during the last two decades have instigated the growing interest in this study to include both βhCG and lipid profile studies in the early second trimester as early predictors of pregnancy-induced hypertension. Early identification of at-risk women may help in taking timely preventive and curative management to prevent or delay complications associated with pregnancy-induced hypertension.
A prospective study was performed on 120 patients attending the outpatient department of the Obstetrics and Gynaecology of the Maharaja Agrasen Hospital. All the patients were screened for serum βhCG and serum lipid profile in their early second trimester (14-20 weeks) and followed up till their delivery. Comparative studies of serum βhCG and serum lipid profile were performed between those who remain normotensive (group I) and those who developed pregnancy-induced hypertension (group II).
TG, total cholesterol, VLDL, and LDL values for those women who developed PIH (group II) were significantly higher than those who remain normotensive (group I), with p value of <0.05 which is statistically significant. HDL and βhCG values for group II were not higher than those in group I with p value >0.05 which is statistically insignificant.
Maternal lipid profile in second trimester is very good noninvasive test which can be used for prediction of pregnancy-induced hypertension before its clinical onset. However, there is no correlation between maternal serum βhCG and pregnancy-induced hypertension.
在过去二十年中，子痫前期病理生理学中涉及的多种生物学、生物化学和生物物理标志物激发了本研究越来越浓厚的兴趣，即将孕中期早期的βhCG和血脂谱研究纳入妊娠高血压的早期预测指标。早期识别高危女性可能有助于及时采取预防和治疗措施，以预防或延迟与妊娠高血压相关的并发症。
对120名在玛哈拉贾·阿格拉森医院妇产科门诊就诊的患者进行了一项前瞻性研究。所有患者在孕中期早期（14 - 20周）进行血清βhCG和血清血脂谱筛查，并随访至分娩。对血压正常者（第一组）和发生妊娠高血压者（第二组）进行血清βhCG和血清血脂谱的比较研究。
发生妊娠高血压（第二组）的女性的甘油三酯、总胆固醇、极低密度脂蛋白和低密度脂蛋白值显著高于血压正常者（第一组），p值<0.05，具有统计学意义。第二组的高密度脂蛋白和βhCG值不高于第一组，p值>0.05，无统计学意义。
孕中期孕妇血脂谱是一种非常好的非侵入性检测方法，可用于在妊娠高血压临床发作前进行预测。然而，孕妇血清βhCG与妊娠高血压之间没有相关性。
