组织因子和组织因子途径抑制剂在溃疡性结肠炎中的表达的临床意义
Clinical significance of expression of tissue factor and tissue factor pathway inhibitor in ulcerative colitis.
作者信息
He Hao-Lan, Zhang Ji-Bin, Li Qian
机构信息
Hao-Lan He, Qian Li, Department of Gastroenterology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China.
出版信息
World J Gastroenterol. 2014 Jun 21;20(23):7461. doi: 10.3748/wjg.v20.i23.7461.
AIM
To investigate the clinical significance of expression of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in ulcerative colitis (UC).
METHODS
Thirty UC specimens taken by colonoscopy from patients with active UC treated at the Department of Pathology, Central Hospital Affiliated to Shenyang Medical College from February 2010 to January 2012 were included in an experimental group, and 30 normal colon tissue samples taken by colonoscopy from non-UC patients were included in a control group. Expression of TF and TFPI in UC and normal colon tissue samples was detected by immunohistochemistry.
RESULTS
The positive rate of TF in UC was significantly higher than that in normal colon tissue (63% vs 33%, χ(2) = 5.41, P < 0.05). The positive rate of TFPI in UC was also significantly higher than that in normal colon tissue (43% vs 17%, χ(2) = 5.08, P < 0.05).
CONCLUSION
Positive rates of TF and TFPI expression in UC are significantly higher than those in normal colon tissue. TF and TFPI may play an important role in the pathogenesis of UC.
目的
探讨组织因子（TF）和组织因子途径抑制物（TFPI）在溃疡性结肠炎（UC）中的表达及其临床意义。
方法
选取2010年2月至2012年1月在沈阳医学院附属中心医院病理科接受治疗的30例活动期UC患者的结肠镜检查标本作为实验组，另选取30例非UC患者的结肠镜检查正常结肠组织标本作为对照组。采用免疫组织化学法检测UC组织和正常结肠组织中TF和TFPI的表达。
结果
UC组织中TF的阳性率显著高于正常结肠组织（63% 对33%，χ(2)=5.41，P<0.05）。UC组织中TFPI的阳性率也显著高于正常结肠组织（43% 对17%，χ(2)=5.08，P<0.05）。
结论
UC中TF和TFPI的阳性表达率显著高于正常结肠组织。TF和TFPI可能在UC的发病机制中起重要作用。
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