CYP2C9基因变异与白癜风的关联
Association of CYP2C9 Genetic Variants with Vitiligo.
作者信息
Alzolibani Abdullateef A, Al Robaee Ahmad, Al-Shobaili Hani, Al-Saif Fahad, Al-Mekhadab Eman, Settin Ahmed A
机构信息
Department of Dermatology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Ann Dermatol. 2014 Jun;26(3):343-8. doi: 10.5021/ad.2014.26.3.343. Epub 2014 Jun 12.
BACKGROUND
Vitiligo is a depigmenting skin disorder in which genetic factors play an important role.
OBJECTIVE
To examine the association of CYP2C9 () 1/() 2/(*) 3 gene polymorphism with vitiligo.
METHODS
In this case controlled study, 95 Saudi patients with vitiligo (50 men and 45 women), with a mean age of 27.3 years, were analyzed. Patients were compared to 86 healthy controls from the same locality (76 men and 10 women), with a mean age of 20.1 years. In all participants, DNA was extracted and processed for characterization of 2C9 () 1/() 2/(*) 3 gene variants using real time-polymerase chain reaction.
RESULTS
Vitiligo patients have a significantly higher CYP2C9 () 3 allele carriage rate compared to controls (32.7% versus 4.7%, p=0.00, odds ratio=9.9, 95% confidence interval=3.3~29.6). On the other hand, frequencies of CYP2C9 () 2 genotypes and alleles did not show any significant difference between vitiligo cases and controls. When the frequencies of CYP2C9 genotypes were compared among subgroups of age, gender, family history, and disease patterns, the cases with positive consanguinity had significantly higher frequencies of homozygous genotypes than others (p=0.029).
CONCLUSION
CYP2C9 (*) 3 allele carriage is probably associated with vitiligo susceptibility.
背景
白癜风是一种色素脱失性皮肤病，其中遗传因素起重要作用。
目的
研究CYP2C9（）1/（）2/（*）3基因多态性与白癜风的关联。
方法
在这项病例对照研究中，分析了95例沙特白癜风患者（50名男性和45名女性），平均年龄27.3岁。将患者与来自同一地区的86名健康对照者（76名男性和10名女性）进行比较，平均年龄20.1岁。对所有参与者提取DNA，并使用实时聚合酶链反应对2C9（）1/（）2/（*）3基因变异进行特征分析。
结果
与对照组相比，白癜风患者的CYP2C9（）3等位基因携带率显著更高（32.7%对4.7%，p = 0.00，优势比 = 9.9，95%置信区间 = 3.3~29.6）。另一方面，CYP2C9（）2基因型和等位基因的频率在白癜风病例和对照组之间未显示出任何显著差异。当比较CYP2C9基因型在年龄、性别、家族史和疾病模式亚组中的频率时，有近亲关系阳性的病例纯合基因型频率显著高于其他病例（p = 0.029）。
结论
CYP2C9（*）3等位基因携带可能与白癜风易感性相关。
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