Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Biosci Trends. 2010 Dec;4(6):333-7.
Dose requirements for oral anticoagulants in thromboembolic events are influenced by polymorphisms in VKORC1 and CYP2C9 genes. The Indian population comprises multiple ethnic groups but no data is available on allele frequencies of these genes for North Indians. The present study aimed at establishing the allele and genotype frequencies of VKORC1 -1639 G>A, CYP2C92 and CYP2C93 alleles in the North Indian population. One hundred and two healthy subjects from the Northern Indian region were genotyped for VKORC1 -1639 G>A, CYP2C92 and CYP2C93 by polymerase chain reaction and restriction fragment length polymorphism. Allele frequencies were compared with that of the HapMap populations. The allele frequencies for VKORC1 -1639 A, CYP2C92 and CYP2C93 were found to be 14.22%, 4.90% and 3.92% respectively. This report also describes the inter-ethnic differences in the Northern Indian frequencies of VKORC1 -1639 G>A, CYP2C92 and CYP2C93 alleles with that of other populations and HapMap project data. VKORC1 -1639 G>A allele is present at moderately high frequency in the Northern Indian population. The frequencies of CYP2C92 and CYP2C93 alleles are also found to be different from other populations.
血栓栓塞事件中口服抗凝剂的剂量需求受 VKORC1 和 CYP2C9 基因多态性的影响。印度人口由多个族群组成，但目前尚无关于北印度人这些基因等位基因频率的数据。本研究旨在确定北印度人群中 VKORC1-1639 G>A、CYP2C92 和 CYP2C93 等位基因的等位基因和基因型频率。从印度北部地区招募了 102 名健康受试者，通过聚合酶链反应和限制性片段长度多态性对 VKORC1-1639 G>A、CYP2C92 和 CYP2C93 进行基因分型。将等位基因频率与 HapMap 人群进行比较。VKORC1-1639 A、CYP2C92 和 CYP2C93 等位基因的等位基因频率分别为 14.22%、4.90%和 3.92%。本报告还描述了北印度人群中 VKORC1-1639 G>A、CYP2C92 和 CYP2C93 等位基因的种族间差异，以及与其他人群和 HapMap 项目数据的差异。VKORC1-1639 G>A 等位基因在北印度人群中存在中等频率。CYP2C92 和 CYP2C93 等位基因的频率也与其他人群不同。
