外周血干细胞移植后食管黏膜下血肿：病例报告及文献复习
Esophageal intramucosal hematoma after peripheral blood stem cell transplantation: case report and review of literature.
作者信息
Kobayashi Takashi, Seo Sachiko, Morita Shigeki, Goto Akiteru, Masuda Akiko, Shimizu Nobuyuki, Nishida Masato, Nunobe Souya, Ichikawa Motoshi, Takazawa Yutaka, Seto Yasuyuki, Fukayama Masashi, Kurokawa Mineo
机构信息
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
Department of Pathology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan.
出版信息
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2690-4. eCollection 2014.
Esophageal complications occur after hematopoietic stem cell transplantation (HSCT). There are, however, only limited reports on the etiology or management of esophageal complications. Here, we report the occurrence of intramucosal hematoma presenting continuous esophageal hemorrhage in a 34 year-old man following the second peripheral blood stem cell transplantation for acute myeloid leukemia. His hematemesis started 2 months after HSCT and was repeated in supportive care. On day 156, he underwent total esophagectomy as a result of uncontrollable massive hematemesis. Histopathological testings of the resected esophagus confirmed intramucosal hematoma as a cause of hematemesis. This case highlights intramucosal hematoma as one of the important etiologies of esophageal complications following HSCT.
造血干细胞移植（HSCT）后会发生食管并发症。然而，关于食管并发症的病因或处理的报道有限。在此，我们报告一名34岁男性在第二次急性髓系白血病外周血干细胞移植后发生黏膜内血肿并伴有持续性食管出血的病例。他的呕血在HSCT后2个月开始，并在支持治疗过程中反复出现。在第156天，由于无法控制的大量呕血，他接受了全食管切除术。切除食管的组织病理学检查证实黏膜内血肿是呕血的原因。该病例突出了黏膜内血肿是HSCT后食管并发症的重要病因之一。
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