Karalezli Aylin, Kucukerdonmez Cem, Akova Yonca A, Koktekir Bengu Ekinci
Department of Ophthalmology, School of Medicine, Baskent University, Konya 42080 Turkey.
Department of Ophthalmology, School of Medicine, Izmir University, Izmir 35530, Turkey.
Int J Ophthalmol. 2014 Jun 18;7(3):512-6. doi: 10.3980/j.issn.2222-3959.2014.03.23. eCollection 2014.
To assess the effect of topical bevacizumab use on postoperative pterygium recurrence in eyes who underwent pterygium excision with limbal-conjunctival autograft transplantation (LCAT).
Eighty-eight eyes of 88 patients with primary pterygium were included. Pterygia were graded preoperatively from type 1 to type 3 (type 1 atrophic, type 3 inflamed) according to the inflammatory status. The eyes were preoperatively randomized to receive topical steroid and antibiotic treatment (group 1, 46 eyes) and additional topical bevacizumab (5 mg/mL; group 2, 42 eyes) in the postoperative period. All eyes underwent pterygium excision and LCAT. Medications were tapered and discontinued at one month. Postoperative complications and recurrence rates were recorded.
The mean follow-up duration was 29.3±4.2mo (24-52mo) and 28.5±3.4 (24-48mo) in group 1 and 2, respectively (P>0.05). There were no statistically significant differences regarding the age or gender between groups (P>0.05). Also, the difference between groups with respect to pterygium type was not significant. During the follow-up period, recurrence developed in 2 eyes (4.3%) in group 1, whereas in one eye (2.4%) in group 2. No statistically significant difference between groups was found in recurrence rates (P>0.05). No re-operation for recurrence was necessary during the follow-up period in both groups.
Topical bevacizumab seems to have no additonal effect on pterygium recurrence after LCAT.
评估局部使用贝伐单抗对接受翼状胬肉切除联合自体角膜缘结膜移植术（LCAT）的患者术后翼状胬肉复发的影响。
纳入88例原发性翼状胬肉患者的88只眼。根据炎症状态将翼状胬肉术前分为1至3型（1型萎缩型，3型炎症型）。术前将这些眼随机分为两组，一组术后接受局部类固醇和抗生素治疗（第1组，46只眼），另一组在术后额外接受局部贝伐单抗治疗（5mg/mL；第2组，42只眼）。所有眼均接受翼状胬肉切除和LCAT。药物在1个月时逐渐减量并停用。记录术后并发症和复发率。
第1组和第2组的平均随访时间分别为29.3±4.2个月（24 - 52个月）和28.5±3.4个月（24 - 48个月）（P>0.05）。两组之间在年龄或性别方面无统计学显著差异（P>0.05）。此外，两组在翼状胬肉类型方面的差异也不显著。随访期间，第1组有2只眼（4.3%）复发，而第2组有1只眼（2.4%）复发。两组复发率之间未发现统计学显著差异（P>0.05）。随访期间两组均无需因复发进行再次手术。
局部使用贝伐单抗似乎对LCAT术后翼状胬肉复发无额外影响。
