Sun Wen, Sheng Yan, Weng Yu, Xu Chun-Xiao, Williams Susan E I, Liu Yu-Tao, Hauser Michael A, Allingham R Rand, Jin Ming-Juan, Chen Guang-Di
Department of Ophthalmology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China.
Int J Ophthalmol. 2014 Jun 18;7(3):550-6. doi: 10.3980/j.issn.2222-3959.2014.03.29. eCollection 2014.
To study the associations between lysyl oxidase-like 1 (LOXL1) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk.
Published literature from PubMed and other databases were retrieved. All studies evaluating the association between LOXL1 polymorphisms (rs2165241, rs1048661, rs3825942) and POAG risk were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random- or fixed-effects model.
Twelve studies were identified as eligible articles, with thirteen (2098 cases and 16 473 controls), thirteen (1795 cases and 2916 controls) and sixteen population cohorts (2456 cases and 2846 controls) for the association of rs2165241, rs1048661 and rs3825942 with POAG risk respectively. Overall analyses showed no association between each LOXL1 polymorphism and POAG risk, and the negative associations were remained when the subjects were stratified as Caucasian and Asian. The heterozygote of rs2165241 was associated with reduced POAG risk in hospital-based populations (TC vs CC: OR, 0.79, 95%CI: 0.63-0.99), and rs1048661 was associated with increased POAG risk in hospital-based populations in a dominant model (TT vs CC+CT: OR, 1.23, 95%CI: 1.01-1.50); however, these associations were not found in population-based subjects.
This meta-analysis suggests that LOXL1 polymorphisms are not associated with POAG risk. Given the limited sample size, the associations of LOXL1 polymorphisms with POAG risk in hospital-based populations await further investigation.
赖氨酰氧化酶样1（LOXL1）基因多态性与原发性开角型青光眼（POAG）之间的关联仍不一致。在本研究中，我们进行了一项荟萃分析，以探讨LOXL1基因多态性与POAG风险的关联。
检索来自PubMed和其他数据库的已发表文献。纳入所有评估LOXL1基因多态性（rs2165241、rs1048661、rs3825942）与POAG风险之间关联的研究。使用随机或固定效应模型计算合并比值比（OR）和95%置信区间（CI）。
确定了12项研究为合格文章，分别有13个（2098例病例和16473例对照）、13个（1795例病例和2916例对照）和16个群体队列（2456例病例和2846例对照）用于rs2165241、rs1048661和rs3825942与POAG风险关联的研究。总体分析显示，每个LOXL1基因多态性与POAG风险之间均无关联，并且当将受试者按白种人和亚洲人分层时，阴性关联仍然存在。rs2165241的杂合子在基于医院的人群中与POAG风险降低相关（TC与CC：OR，0.79，95%CI：0.63 - 0.99），rs1048661在显性模型中与基于医院的人群中POAG风险增加相关（TT与CC + CT：OR，1.23，95%CI：1.01 - 1.50）；然而，在基于人群的受试者中未发现这些关联。
这项荟萃分析表明，LOXL1基因多态性与POAG风险无关。鉴于样本量有限，LOXL1基因多态性与基于医院人群中POAG风险的关联有待进一步研究。
