• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

赖氨酰氧化酶样1基因多态性与原发性开角型青光眼的关联：基于5293名受试者的荟萃分析

Associations of polymorphisms of LOXL1 gene with primary open-angle glaucoma: a meta-analysis based on 5,293 subjects.

作者信息

Wu Mingyu, Zhu Xiao-Yan, Ye Jian

机构信息

Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

出版信息

Mol Vis. 2015 Feb 13;21:165-72. eCollection 2015.

PMID:25750511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4333729/
Abstract

OBJECTIVE

Previous studies indicated that the relationship between lysyl oxidase-like 1 (LOXL1) gene polymorphisms and primary open-angle glaucoma (POAG) remains inconsistent. In the present study, we aimed to perform a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG risk.

METHODS

Literatures were electronically searched in the PubMed, EMBASE, CNKI, Wanfang, and VIP databases. The published literatures, which are case-control or cohort studies on the relationship between the polymorphisms (rs1048661, rs3825942, rs2165241) of the LOXL1 gene and POAG, were documented.

RESULTS

We included 13 literatures including 5,293 subjects for the present study. A meta-analysis showed that the risk of POAG in individuals carrying the C allele of rs2165241 was 1.26 times higher compared with those carrying the T allele (odds ratio (OR)=1.26, 95% confidence interval (CI): 1.091.46) in the total population. In the Caucasian population, we also found that individuals carrying the C allele of rs2165241 have an increased risk for POAG compared to those subjects carrying the T allele (OR=1.42, 95% CI: 1.191.69, p=0.0001). In addition, we found that the rs1048661 polymorphism was associated with POAG in the Asian population (OR=1.17, 95% CI: 1.021.35, p=0.03), and rs3825942 was associated with POAG in the Caucasian population (OR=2.69, 95% CI: 1.614.47, p<0.001).

CONCLUSIONS

The polymorphisms of the LOXL1 gene were associated with the susceptibility of POAG.

摘要

目的

既往研究表明赖氨酰氧化酶样1（LOXL1）基因多态性与原发性开角型青光眼（POAG）之间的关系尚无定论。在本研究中，我们旨在进行一项荟萃分析，以探讨LOXL1基因多态性与POAG风险之间的关联。

方法

通过电子检索PubMed、EMBASE、中国知网、万方和维普数据库中的文献。纳入已发表的关于LOXL1基因多态性（rs1048661、rs3825942、rs2165241）与POAG关系的病例对照研究或队列研究文献。

结果

本研究共纳入13篇文献，涉及5293名受试者。荟萃分析显示，在总体人群中，携带rs2165241基因C等位基因的个体患POAG的风险是携带T等位基因个体的1.26倍（比值比（OR）=1.26，95%置信区间（CI）：1.091.46）。在白种人群中，我们还发现携带rs2165241基因C等位基因的个体患POAG的风险高于携带T等位基因的个体（OR=1.42，95%CI：1.191.69，p=0.0001）。此外，我们发现rs1048661基因多态性与亚洲人群的POAG相关（OR=1.17，95%CI：1.021.35，p=0.03），rs3825942基因多态性与白种人群的POAG相关（OR=2.69，95%CI：1.614.47，p<0.0

01）。

结论

LOXL1基因多态性与POAG易感性相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bd81d641b8be/mv-v21-165-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/2eb82a2b71a8/mv-v21-165-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/f86fb473a5f2/mv-v21-165-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/732248d94dbd/mv-v21-165-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bc2e586f003f/mv-v21-165-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bf1e45da54e8/mv-v21-165-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/b6246eb19b91/mv-v21-165-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/e8b5b5d15da6/mv-v21-165-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bd81d641b8be/mv-v21-165-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/2eb82a2b71a8/mv-v21-165-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/f86fb473a5f2/mv-v21-165-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/732248d94dbd/mv-v21-165-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bc2e586f003f/mv-v21-165-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bf1e45da54e8/mv-v21-165-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/b6246eb19b91/mv-v21-165-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/e8b5b5d15da6/mv-v21-165-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad7f/4333729/bd81d641b8be/mv-v21-165-f8.jpg

相似文献

1
Associations of polymorphisms of LOXL1 gene with primary open-angle glaucoma: a meta-analysis based on 5,293 subjects.赖氨酰氧化酶样1基因多态性与原发性开角型青光眼的关联：基于5293名受试者的荟萃分析
Mol Vis. 2015 Feb 13;21:165-72. eCollection 2015.
2
Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population.维吾尔族人群剥脱综合征中LOXL1基因多态性的评估
Mol Vis. 2011;17:1734-44. Epub 2011 Jun 28.
3
[Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population].[四川人群中LOXL1基因多态性与原发性开角型青光眼的关联]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Feb;32(1):89-93. doi: 10.3760/cma.j.issn.1003-9406.2015.01.020.
4
Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese.中国南方和北方原发性开角型青光眼中LOXL1基因多态性的评估。
Mol Vis. 2008;14:2381-9. Epub 2008 Dec 19.
5
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.剥脱综合征和剥脱性青光眼中LOXL1基因多态性的评估。
Mol Vis. 2008 Mar 17;14:533-41.
6
Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.基于种族的LOXL1基因多态性与青光眼关联的亚组荟萃分析。
Mol Vis. 2010 Feb 6;16:167-77.
7
Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome.日本原发性开角型青光眼和剥脱综合征患者赖氨酰氧化酶样1基因多态性
Mol Vis. 2008 Jul 14;14:1303-8.
8
Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.土耳其人群中LOXL1基因多态性与剥脱综合征/青光眼及原发性开角型青光眼的关联
Mol Vis. 2013;19:114-20. Epub 2013 Jan 28.
9
Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis.赖氨酰氧化酶样1基因多态性与原发性开角型青光眼之间无关联：一项荟萃分析。
Int J Ophthalmol. 2014 Jun 18;7(3):550-6. doi: 10.3980/j.issn.2222-3959.2014.03.29. eCollection 2014.
10
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.在三个不同人群中，赖氨酰氧化酶样蛋白1（LOXL1）变体与原发性开角型青光眼之间不存在关联。
Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3465-8. doi: 10.1167/iovs.08-1850. Epub 2008 Apr 17.

引用本文的文献

1
Asian Race and Primary Open-Angle Glaucoma: Where Do We Stand?亚洲人种与原发性开角型青光眼：我们目前的状况如何？
J Clin Med. 2022 Apr 28;11(9):2486. doi: 10.3390/jcm11092486.
2
gene polymorphism candidates for exfoliation glaucoma are also associated with a risk for primary open-angle glaucoma in a Caucasian population from central Russia.在来自俄罗斯中部的白种人群体中，剥脱性青光眼的候选基因多态性也与原发性开角型青光眼的风险相关。
Mol Vis. 2021 May 8;27:262-269. eCollection 2021.
3
LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.

本文引用的文献

1
Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk.与剥脱性青光眼相关的基因多态性也与原发性开角型青光眼的风险相关。
Clin Exp Ophthalmol. 2015 Jan-Feb;43(1):26-30. doi: 10.1111/ceo.12367. Epub 2014 Aug 7.
2
The pathophysiology and treatment of glaucoma: a review.青光眼的病理生理学和治疗：综述。
JAMA. 2014 May 14;311(18):1901-11. doi: 10.1001/jama.2014.3192.
3
Correlation of pattern reversal visual evoked potential parameters with the pattern standard deviation in primary open angle glaucoma.
LOXL1 基因多态性与剥脱综合征/剥脱性青光眼风险相关：一项更新的荟萃分析。
PLoS One. 2021 Apr 28;16(4):e0250772. doi: 10.1371/journal.pone.0250772. eCollection 2021.
4
Association of Gene Polymorphisms with Exfoliation Glaucoma Patients.基因多态性与剥脱性青光眼患者的关联
Iran J Public Health. 2019 Oct;48(10):1827-1837.
5
Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner.αvβ3 整合素的激活以 ROCK 非依赖性方式改变人眼小梁细胞中的纤维连接蛋白纤维形成。
Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3897-3913. doi: 10.1167/iovs.19-27171.
6
Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis.TLR4 多态性与开角型青光眼的相关性：荟萃分析。
Biomed Res Int. 2019 Jul 24;2019:6707650. doi: 10.1155/2019/6707650. eCollection 2019.
7
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.全基因组关联研究鉴定出原发性开角型青光眼的 7 个新的易感位点。
Hum Mol Genet. 2018 Apr 15;27(8):1486-1496. doi: 10.1093/hmg/ddy053.
8
Disruption of fibronectin matrix affects type IV collagen, fibrillin and laminin deposition into extracellular matrix of human trabecular meshwork (HTM) cells.纤连蛋白基质的破坏会影响IV型胶原蛋白、原纤蛋白和层粘连蛋白在人小梁网（HTM）细胞的细胞外基质中的沉积。
Exp Eye Res. 2017 Dec;165:7-19. doi: 10.1016/j.exer.2017.08.017. Epub 2017 Aug 30.
9
The SPARC-related modular calcium binding protein 2 () gene polymorphism in primary glaucoma: a case-control study.原发性青光眼患者中与富含半胱氨酸的酸性分泌蛋白相关的模块化钙结合蛋白2（）基因多态性：一项病例对照研究。
Clin Ophthalmol. 2017 Mar 20;11:549-555. doi: 10.2147/OPTH.S126459. eCollection 2017.
原发性开角型青光眼患者图形翻转视觉诱发电位参数与图形标准差的相关性
Int J Ophthalmol. 2014 Apr 18;7(2):326-9. doi: 10.3980/j.issn.2222-3959.2014.02.24. eCollection 2014.
4
Common sequence variants in the LOXL1 gene in pigment dispersion syndrome and pigmentary glaucoma.LOXL1 基因中的常见序列变异与色素播散综合征和色素性青光眼有关。
BMC Ophthalmol. 2014 Apr 16;14:52. doi: 10.1186/1471-2415-14-52.
5
Intraocular pressure after phacoemulsification in patients with uncontrolled primary open angle glaucoma.原发性开角型青光眼控制不佳患者白内障超声乳化术后的眼压
J Med Life. 2014 Mar 15;7(1):11-6. Epub 2014 Mar 25.
6
The genetics of intraocular pressure.眼压的遗传学
Semin Ophthalmol. 2013 Sep-Nov;28(5-6):301-5. doi: 10.3109/08820538.2013.825291.
7
Review: The role of LOXL1 in exfoliation syndrome/glaucoma.综述：赖氨酰氧化酶样蛋白1在剥脱综合征/青光眼中的作用
Saudi J Ophthalmol. 2011 Oct;25(4):347-52. doi: 10.1016/j.sjopt.2011.07.001. Epub 2011 Jul 27.
8
Association of glutathione S-transferase polymorphisms (GSTM1 and GSTT1) with primary open-angle glaucoma: an evidence-based meta-analysis.谷胱甘肽 S-转移酶多态性（GSTM1 和 GSTT1）与原发性开角型青光眼的关联：基于证据的荟萃分析。
Gene. 2013 Sep 10;526(2):80-6. doi: 10.1016/j.gene.2013.05.032. Epub 2013 Jun 4.
9
Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.土耳其人群中LOXL1基因多态性与剥脱综合征/青光眼及原发性开角型青光眼的关联
Mol Vis. 2013;19:114-20. Epub 2013 Jan 28.
10
Biomarkers in primary open angle glaucoma.原发性开角型青光眼的生物标志物。
Clin Chem Lab Med. 2012 Dec;50(12):2107-19. doi: 10.1515/cclm-2012-0048.