Elkabbaj Driss, Bahadi Abdelali, Cherrah Yahia, Errasfa Mourad, Eljaoudi Rachid
Nephrology Department, Military Hospital Mohammed V, 10000 Rabat, Morocco.
Pharmacology and Toxicology Department, Faculty of Medicine and Pharmacy, 10000 Rabat, Morocco.
ISRN Nephrol. 2012 Dec 19;2013:717849. doi: 10.5402/2013/717849. eCollection 2013.
The aim of this study was to evaluate the levels of malondialdehyde as an oxidative stress marker in the same hemodialysis patients after changing the quality of dialysate with ultrapure dialysis fluid. Methods. This prospective study concerns hemodialysis patients; all patients were in the first step treated with conventional dialysate, and in the second step (three months later) the same patients were treated with online produced ultrapure dialysis fluid. The malondialdehyde, C-reactive protein, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, fibrinogen, and albumin were quantified before the two steps. Results. Thirty-seven patients completed the study. Ultrapure dialysis fluid reduced but not significantly the malondialdehyde concentrations. Both dialysis fluids were associated with improvement in the malondialdehyde level before and after the hemodialysis session. In lipid parameters, there was a significant decrease with conventional dialysis fluid versus ultrapure dialysis fluid of triglycerides, total cholesterol, and high-density lipoprotein in patients' blood. Instead, the level of low-density lipoprotein, fibrinogen, albumin, and C-reactive protein does not change significantly. Conclusion. The lipid parameters were improved for triglycerides and total cholesterol. Malondialdehyde increases following the hemodialysis session, and the conventional dialysate increased malondialdehyde levels more than the ultrapure dialysis but the differences were not statistically significant.
本研究的目的是评估在使用超纯透析液改变透析液质量后，同一血液透析患者体内作为氧化应激标志物的丙二醛水平。方法。这项前瞻性研究涉及血液透析患者；所有患者第一步先用传统透析液治疗，第二步（三个月后）同一批患者改用在线生产的超纯透析液治疗。在这两个步骤之前对丙二醛、C反应蛋白、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、纤维蛋白原和白蛋白进行定量。结果。37名患者完成了研究。超纯透析液降低了丙二醛浓度，但降幅不显著。两种透析液均与血液透析前后丙二醛水平的改善有关。在血脂参数方面，与超纯透析液相比，传统透析液使患者血液中的甘油三酯、总胆固醇和高密度脂蛋白显著降低。相反，低密度脂蛋白、纤维蛋白原、白蛋白和C反应蛋白水平没有显著变化。结论。甘油三酯和总胆固醇的血脂参数得到改善。血液透析后丙二醛增加，传统透析液比超纯透析液使丙二醛水平升高得更多，但差异无统计学意义。
