[Pd(μ-Cl)Cl(IPr*)]₂：一种用于通过格氏试剂交叉偶联合成四邻位取代联芳基的高度受阻预催化剂。
[Pd(μ-Cl)Cl(IPr*)]2: a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling.
作者信息
Lesieur Mathieu, Slawin Alexandra M Z, Cazin Catherine S J
机构信息
EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK.
出版信息
Org Biomol Chem. 2014 Aug 14;12(30):5586-9. doi: 10.1039/c4ob01269k. Epub 2014 Jun 26.
PMID:24967551
Abstract
The new well-defined catalyst [Pd(μ-Cl)Cl(IPr*)]2 enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.
摘要
新型结构明确的催化剂[Pd(μ-Cl)Cl(IPr*)]2能够实现高效的格氏试剂交叉偶联反应，用于合成四邻位取代的联芳基化合物。该配合物的高反应活性与IPr*配体的重要空间位阻有关。对于这一具有挑战性的转化反应，该二聚体是迄今为止报道的最有效的催化剂。
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