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群体遗传学在医学领域的应用

[Application of population genetics in the field of medicine].

作者信息

Octavio-Aguilar Pablo, Ramos-Frías Josefina

机构信息

Laboratorio de Genética Evolutiva y Ambiental, Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Hidalgo.

出版信息

Biomedica. 2014 Apr-Jun;34(2):171-9. doi: 10.1590/S0120-41572014000200004.

Abstract

Human populations follow the same evolutionary principles as other organisms, although mixed with social and cultural elements, which can result in a high prevalence of certain diseases within specific ethnic groups. In this work, the Hardy-Weinberg principle is analyzed from a medical, social and biological viewpoint to understand the evolutionary processes of autosomal recessive diseases. It can be concluded that the incidence of these diseases is inversely related to the levels of genetic variability within populations, which depends on colonization, recolonization and migration events, as well as on social conventions such as racism, social stratification and segregation.

摘要

人类群体遵循与其他生物相同的进化原则,尽管其中混杂着社会和文化因素,这可能导致某些疾病在特定种族群体中高发。在这项研究中,从医学、社会和生物学角度分析了哈迪-温伯格原理,以了解常染色体隐性疾病的进化过程。可以得出结论,这些疾病的发病率与群体内的遗传变异水平呈负相关,而群体内的遗传变异水平取决于殖民、重新殖民和迁移事件,以及种族主义、社会分层和隔离等社会习俗。

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