Bhandari Ritu, van der Veen Rixt, Parsons Christine E, Young Katherine S, Voorthuis Alexandra, Bakermans-Kranenburg Marian J, Stein Alan, Kringelbach Morten L, van IJzendoorn Marinus H
a Centre for Child and Family Studies , Leiden University , Leiden , Netherlands.
Soc Neurosci. 2014;9(5):536-47. doi: 10.1080/17470919.2014.932307. Epub 2014 Jun 26.
Oxytocin has been implicated in parent-infant attachment and social recognition. With respect to emotion recognition memory, both memory-enhancing and impairing effects have been observed, suggesting an influence of individual factors. We assessed the effects of oxytocin on memory for infant cues, and whether these effects are moderated by self-reported childhood emotional maltreatment. Nulliparous females (N = 102) participated in a randomized, double-blind, between-subjects study with intranasal oxytocin or placebo administration. Participants' memory was tested using the Baby Social Reward Task, where participants were asked to select the happier infant from a pair of two infants based on the information that they received about the infants' mood in the previous phase. Participants reporting more childhood emotional maltreatment were less accurate in this task after inhaling oxytocin. Our findings add to a growing body of literature showing that the effects of intranasal oxytocin on memory and social behavior are moderated by adverse early life experiences.
催产素与母婴依恋和社会认知有关。关于情绪识别记忆，已观察到其既有增强记忆的作用，也有损害记忆的作用，这表明存在个体因素的影响。我们评估了催产素对婴儿线索记忆的影响，以及这些影响是否会受到自我报告的童年期情感虐待的调节。未生育女性（N = 102）参与了一项随机、双盲、受试者间的研究，接受鼻内催产素或安慰剂给药。使用婴儿社会奖励任务对参与者的记忆进行测试，在该任务中，要求参与者根据他们在前一阶段获得的关于婴儿情绪的信息，从一对婴儿中选择更快乐的婴儿。报告童年期情感虐待较多的参与者在吸入催产素后完成这项任务的准确性较低。我们的研究结果进一步丰富了越来越多的文献，表明鼻内催产素对记忆和社会行为的影响会受到早期不良生活经历的调节。
