双层屏障作为一种降低布洛芬释放速率的有效方法。
Double barrier as an effective method for slower delivery rate of ibuprofen.
作者信息
Kurczewska Joanna, Lewandowski Dawid, Olejnik Anna, Schroeder Grzegorz, Nowak Izabela
机构信息
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Umultowska 89B, Poznań 61-614, Poland.
出版信息
Int J Pharm. 2014 Sep 10;472(1-2):248-50. doi: 10.1016/j.ijpharm.2014.06.037. Epub 2014 Jun 23.
Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-loaded alginate beads and MCM-41_IBU. The IBU release from alginate matrix can be controlled by adjusting the free IBU/MCM-41_IBU ratio.
选择布洛芬（IBU）作为模型药物来研究药物释放速率。介孔MCM-41已负载布洛芬（MCM-41_IBU）。海藻酸钙用于包封游离药物和介孔材料。具有双重屏障的体系显示出IBU的释放比游离布洛芬负载的海藻酸盐珠和MCM-41_IBU更慢。海藻酸盐基质中IBU的释放可通过调节游离IBU/MCM-41_IBU的比例来控制。
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