Pal Goutam
J Indian Med Assoc. 2013 Sep;111(9):612-4, 617.
To evaluate the effects of pegylated Interferon--alpha2B on mumps orchitis, 80 patients suffering from mumps orchitis, were randomly assigned into 2 groups of 40 patients each. In the first group patients received pegylated interferon--alpha2B and the other group did not, acting as controls. All were confirmed by mumps IgM (ELISA) and evaluated by testis size, semen analysis and hormone level. In the first group, the symptoms resolved within average 2.2 days and testicular size returned to normal within average 5.3 days but in 2nd group, those returned to normal within average 5.7 days and 10.2 days respectively. In the 1st group, oligospermia was detected in 11 patients and subsequently returned to normal in all patients and there was no testicular atrophy. In the 2nd group oligospermia was detected in 13 patients and were persistently low in 3 patients and testicular atrophy detected in 2 patients. The results indicated the beneficial role of pegylated interferon--alpha2B in preventing infertility from mumps orchitis.
为评估聚乙二醇化干扰素α-2B对流行性腮腺炎性睾丸炎的疗效，将80例流行性腮腺炎性睾丸炎患者随机分为两组，每组40例。第一组患者接受聚乙二醇化干扰素α-2B治疗，另一组作为对照组不接受治疗。所有患者均通过腮腺炎IgM（酶联免疫吸附测定法）确诊，并通过睾丸大小、精液分析和激素水平进行评估。第一组患者症状平均在2.2天内缓解，睾丸大小平均在5.3天内恢复正常；而第二组患者症状平均在5.7天内缓解，睾丸大小平均在10.2天内恢复正常。第一组有11例患者检测出少精子症，随后所有患者均恢复正常，且无睾丸萎缩情况。第二组有13例患者检测出少精子症，其中3例患者的精子数量持续偏低，2例患者检测出睾丸萎缩。结果表明聚乙二醇化干扰素α-2B在预防流行性腮腺炎性睾丸炎导致的不育方面具有有益作用。
