Sabench Pereferrer Fàtima, Vives Espelta Margarida, Cabrera Vilanova Arantxa, Hernández González Mercè, Feliu Rovira Albert, Blanco Blasco Santiago, Molina López Alicia, Beltrán Nebot Raul, Joven Maried Jorge, Del Castillo Déjardin Daniel
Surgery Unit of the Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Tarragona, Spain,
Obes Surg. 2015 Jan;25(1):55-63. doi: 10.1007/s11695-014-1345-4.
Metabolic surgery can modulate weight as well as food intake and basal energy expenditure. In this study, we evaluate the effectiveness of duodenal exclusion by analysing anthropometric results, intake variations, food behaviour and calorimetric parameters.
This is an experimental study with 8-week-old Sprague-Dawley male rats. The sequences used are as follows: Cafeteria diet for 3 weeks, followed by surgery and sacrifice at 4 weeks. Four experimental groups are as follows: two non-obese groups (n = 15; surgery = 10, sham = 5) and two obese groups by cafeteria diet (n = 15; surgery = 10, sham = 5). Surgery performed was duodenal exclusion with physical barrier. Weight, intake, glycaemia and basal energy expenditure by indirect calorimetry were monitored before and after surgery.
Weight changes in groups that underwent intervention were significant. The reduction in calorie consumption after surgery was significant in the obese intervention group despite an increased standard feed consumption (161 ± 11 vs 139 ± 13 Kcal/day, p < 0.05; due to a lower consumption of cafeteria diet). In non-obese animals, changes were transient. Basal energy expenditure decreased in both intervention groups: 6.2 ± 0.5 vs 5.5 ± 0.4 Kcal/kg/h in non-obese animals and 5.6 ± 0.3 vs 4.7 ± 0.3 Kcal/kg/h in obese animals (p < 0.05).
Duodeno-jejunal tube placement stops weight gain in obese and non-obese animals. In obese animals, there is an important qualitative change in appetite towards standard feed with a significant decrease in caloric intake. In non-obese animals, changes in quantitative intake are transient. This surgery decreases basal energy expenditure in obese animals. This may be attributed to an enhanced thermogenic effect of food and a slowing in the animal's weight gain.
代谢手术可调节体重、食物摄入量和基础能量消耗。在本研究中，我们通过分析人体测量结果、摄入量变化、饮食行为和热量参数来评估十二指肠切除术的有效性。
这是一项针对8周龄雄性斯普拉格-道利大鼠的实验研究。所用序列如下：3周的自助饮食，然后在4周时进行手术并处死。四个实验组如下：两个非肥胖组（n = 15；手术组 = 10，假手术组 = 5）和两个通过自助饮食形成的肥胖组（n = 15；手术组 = 10，假手术组 = 5）。实施的手术是使用物理屏障进行十二指肠切除术。在手术前后监测体重、摄入量、血糖和通过间接测热法测得的基础能量消耗。
接受干预的组体重变化显著。尽管标准饲料消耗量增加（161±11 vs 139±13千卡/天，p < 0.05；原因是自助饮食的消耗量降低），但肥胖干预组术后卡路里消耗量的减少仍很显著。在非肥胖动物中，变化是短暂的。两个干预组的基础能量消耗均下降：非肥胖动物中从6.2±0.5降至5.5±0.4千卡/千克/小时，肥胖动物中从5.6±0.3降至4.7±0.3千卡/千克/小时（p < 0.05）。
十二指肠空肠置管可阻止肥胖和非肥胖动物体重增加。在肥胖动物中，对标准饲料的食欲发生了重要的质的变化，热量摄入量显著减少。在非肥胖动物中，定量摄入量的变化是短暂的。这种手术降低了肥胖动物的基础能量消耗。这可能归因于食物产热效应增强以及动物体重增加放缓。
