Delacourte A, Buée L
Unité I.N.S.E.R.M. n. 16, Laboratoire de Neurosciences, Faculté de Médecine de Lille.
C R Acad Sci III. 1989;308(13):359-65.
GFAP (Glial Fibrillary Acidic protein) was quantified in unfractionated homogenates of different brain regions from 10 Alzheimer patients versus 25 controls using immunoblot techniques and anti-human GFAP. There was a strong increase of GFAP in the brain regions that contained the characteristic Alzheimer lesions. This corresponds to the "astrocytic gliosis". Moreover, there was a 11 fold GFAP increase (p less than 0.001) in the other regions of the Alzheimer brains that do not present the Alzheimer pathology, such as caudate nucleus, cerebellum or brain stem. Different from the gliosis, the physiological signification of such an increase in the whole brain is unknown, but it might reflect the prominent part played by astrocytes during Alzheimer's disease (AD).
使用免疫印迹技术和抗人胶质纤维酸性蛋白（GFAP），对10名阿尔茨海默病患者与25名对照者不同脑区的未分级匀浆中的GFAP进行了定量分析。在含有典型阿尔茨海默病病变的脑区中，GFAP显著增加。这与“星形胶质细胞增生”相符。此外，在未出现阿尔茨海默病病理特征的阿尔茨海默病患者大脑的其他区域，如尾状核、小脑或脑干中，GFAP增加了11倍（p小于0.001）。与胶质细胞增生不同，这种全脑范围内增加的生理意义尚不清楚，但它可能反映了星形胶质细胞在阿尔茨海默病（AD）中所起的重要作用。
