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通过伯胺、甲醛、芳基硼酸和炔烃的合理设计多组分反应合成叔炔丙胺。

Synthesis of tertiary propargylamines via a rationally designed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes.

作者信息

Wang Jiayi, Shen Qiaoying, Li Pinzhen, Peng Yanqing, Song Gonghua

机构信息

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, P. R. China.

出版信息

Org Biomol Chem. 2014 Aug 14;12(30):5597-600. doi: 10.1039/c4ob01055h. Epub 2014 Jun 27.

DOI:10.1039/c4ob01055h
PMID:24969221
Abstract

A novel approach for the synthesis of tertiary propargylamines is achieved through a Cu(OAc)2-catalyzed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes, where a combination of PBM and A(3)-coupling reactions is involved in this new multicomponent reaction.

摘要

通过醋酸铜催化的伯胺、甲醛、芳基硼酸和炔烃的多组分反应，实现了一种合成叔炔丙胺的新方法，其中该新型多组分反应涉及PBM和A(3)-偶联反应的组合。

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Synthesis of tertiary propargylamines via a rationally designed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes.通过伯胺、甲醛、芳基硼酸和炔烃的合理设计多组分反应合成叔炔丙胺。
Org Biomol Chem. 2014 Aug 14;12(30):5597-600. doi: 10.1039/c4ob01055h. Epub 2014 Jun 27.
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