Zhang Ling, Song Fang-Fang, Huang Yu-Bei, Zheng Hong, Song Feng-Ju, Chen Ke-Xin
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China E-mail :
Asian Pac J Cancer Prev. 2014;15(11):4617-22. doi: 10.7314/apjcp.2014.15.11.4617.
Several studies have previously focused on associations between the (GT)n repeat polymorphism of the heme oxygenase-1 (HO-1) gene promoter region and risk of cancers, but results are complex. We conducted the present meta-analysis to integrate relevant findings and evaluate the association between HO-1 (GT)n repeat polymorphism and cancer susceptibility.
Published literature was retrieved from the PubMed/MEDLINE, EMBASE and ISI Web of Science databases before November 2013. For all alleles and genotypes, odds ratios were pooled to assess the strength of the associations using either fixed-effects or random-effects models according to heterogeneity. Subgroup analysis was conducted according to ethnicity and histopathology.
A total of 10 studies involving 2,367 cases and 2,870 controls were identified. The results showed there was no association between HO-1 (GT)n repeat polymorphism and the cancer risk both at the allelic and genotypic level. However, in the stratified analysis, we observed an increased risk of squamous cell carcinoma in persons carrying the LL genotype and the LL+LS genotype as compared with those carrying the SS genotype. When the LS and SS genotypes were combined, the odds ratio for squamous cell carcinoma in LL-genotype carriers, were also significantly increased. No publication bias was observed.
The LL genotype and L-allele carrying genotypes (LL+LS) of HO-1 (GT)n repeat polymorphism are potential genetic factors for developing squamous cell carcinoma. More large and well-designed studies are required for further validations.
此前已有多项研究聚焦于血红素加氧酶-1（HO-1）基因启动子区域的（GT）n重复多态性与癌症风险之间的关联，但结果较为复杂。我们进行了本次荟萃分析，以整合相关研究结果并评估HO-1（GT）n重复多态性与癌症易感性之间的关联。
检索了2013年11月之前PubMed/MEDLINE、EMBASE和ISI Web of Science数据库中发表的文献。对于所有等位基因和基因型，根据异质性，使用固定效应模型或随机效应模型合并比值比，以评估关联强度。根据种族和组织病理学进行亚组分析。
共纳入10项研究，涉及2367例病例和2870例对照。结果显示，在等位基因和基因型水平上，HO-1（GT）n重复多态性与癌症风险之间均无关联。然而，在分层分析中，我们观察到携带LL基因型和LL+LS基因型的人患鳞状细胞癌的风险高于携带SS基因型的人。当LS和SS基因型合并时，LL基因型携带者患鳞状细胞癌的比值比也显著增加。未观察到发表偏倚。
HO-1（GT）n重复多态性的LL基因型和携带L等位基因的基因型（LL+LS）是发生鳞状细胞癌的潜在遗传因素。需要更多大规模、设计良好的研究进行进一步验证。
