Lahiff Conor, Cournane Seán, Creagh Donnacha, Fitzgerald Brian, Conway Richard, Byrne Declan, Silke Bernard
Division of Internal Medicine, St. James's Hospital, Dublin 8, Ireland.
Medical Physics and Bioengineering Department, St. James's Hospital, Dublin 8, Ireland.
Eur J Intern Med. 2014 Sep;25(7):633-8. doi: 10.1016/j.ejim.2014.06.004. Epub 2014 Jun 23.
Important outcome predictor variables for emergency medical admissions are the Manchester Triage Category, Acute Illness Severity, Chronic Disabling Disease and Sepsis Status. We have examined whether these are also predictors of hospital episode costs.
All patients admitted as medical emergencies between January 2008 and December 2012 were studied. Costs per case were adjusted by reference to the relative cost weight of each diagnosis related group (DRG) but included all pay costs, non-pay costs and infra-structural costs. We used a multi-variate logistic regression with generalized estimating equations (GEE), adjusted for correlated observations, to model the prediction of outcome (30-day in-hospital mortality) and hospital costs above or below the median. We used quantile regression to model total episode cost prediction over the predictor distribution (quantiles 0.25, 0.5 and 0.75).
The multivariate model, using the above predictor variables, was highly predictive of an in-hospital death-AUROC of 0.91 (95% CI: 0.90, 0.92). Variables predicting outcome similarly predicted hospital episode cost; however predicting costs above or below the median yielded a lower AUROC of 0.73 (95% CI: 0.73, 0.74). Quantile regression analysis showed that hospital episode costs increased disproportionately over the predictor distribution; ordinary regression estimates of hospital episode costs over estimated the costs for low risk and under estimated those for high-risk patients.
Predictors of outcome also predict costs for emergency medical admissions; however, due to costing data heteroskedasticity and the non-linear relationship between dependant and predictor variables, the hospital episode costs are not as easy to predict based on presentation status.
急诊入院的重要预后预测变量包括曼彻斯特分诊类别、急性疾病严重程度、慢性致残性疾病和脓毒症状态。我们研究了这些变量是否也是住院费用的预测因素。
对2008年1月至2012年12月期间因医疗急诊入院的所有患者进行研究。每个病例的费用根据每个诊断相关组(DRG)的相对成本权重进行调整,但包括所有付费成本、非付费成本和基础设施成本。我们使用带有广义估计方程(GEE)的多变量逻辑回归,并针对相关观察值进行调整,以对结局(30天住院死亡率)以及高于或低于中位数的住院费用进行预测建模。我们使用分位数回归对预测变量分布(分位数0.25、0.5和0.75)上的总住院费用预测进行建模。
使用上述预测变量的多变量模型对院内死亡具有高度预测性——曲线下面积(AUROC)为0.91(95%置信区间:0.90,0.92)。预测结局的变量同样可预测住院费用;然而,预测高于或低于中位数的费用时,曲线下面积较低,为0.73(95%置信区间:0.73,0.74)。分位数回归分析表明,住院费用在预测变量分布上的增长不成比例;住院费用的普通回归估计高估了低风险患者的费用,低估了高风险患者的费用。
结局预测因素也可预测急诊入院的费用;然而,由于成本数据的异方差性以及因变量和预测变量之间的非线性关系,基于就诊状态预测住院费用并非易事。