Systems Proteomics Center Laboratory, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, Escuela de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia.
Systems Proteomics Center Laboratory and Program in Molecular Biology and Biotechnology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Biomolecules. 2012 Mar 1;2(1):143-64. doi: 10.3390/biom2010143.
Mortalin is a highly conserved heat-shock chaperone usually found in multiple subcellular locations. It has several binding partners and has been implicated in various functions ranging from stress response, control of cell proliferation, and inhibition/prevention of apoptosis. The activity of this protein involves different structural and functional mechanisms, and minor alterations in its expression level may lead to serious biological consequences, including neurodegeneration. In this article we review the most current data associated with mortalin's binding partners and how these protein-protein interactions may be implicated in apoptosis and neurodegeneration. A complete understanding of the molecular pathways in which mortalin is involved is important for the development of therapeutic strategies for cancer and neurodegenerative diseases.
线粒体蛋白是一种高度保守的热休克伴侣蛋白，通常存在于多种亚细胞位置。它有几个结合伴侣，并被牵涉到各种功能，从应激反应、控制细胞增殖和抑制/预防细胞凋亡。该蛋白质的活性涉及不同的结构和功能机制，其表达水平的微小变化可能导致严重的生物学后果，包括神经退行性变。在本文中，我们回顾了与线粒体蛋白结合伴侣相关的最最新数据，以及这些蛋白质-蛋白质相互作用如何与细胞凋亡和神经退行性变有关。对线粒体蛋白参与的分子途径的全面了解对于开发癌症和神经退行性疾病的治疗策略是重要的。
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