内皮素对豚鼠离体气道的强烈收缩作用。
Potent contractile effect of endothelin in isolated guinea-pig airways.
作者信息
Maggi C A, Patacchini R, Giuliani S, Meli A
机构信息
Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy.
出版信息
Eur J Pharmacol. 1989 Jan 24;160(1):179-82. doi: 10.1016/0014-2999(89)90670-5.
Endothelin produced a concentration-dependent (1 nM-0.3 microM) contraction of isolated guinea-pig airways (trachea and main bronchi). The response was unaffected by tetrodotoxin (1 microM) and slightly depressed by indomethacin (5 microM) but promptly abolished by isoprenaline (1 microM) or EDTA (3 mM). In the bronchi, the response to endothelin was enhanced by removal (rubbing) of the epithelium. The response of the trachea or bronchi to endothelin (0.3 microM) was unaffected by NiCl2 (0.1 mM) or omega conotoxin (0.1 microM) but was partially inhibited by nifedipine (1 microM).
内皮素可使离体豚鼠气道（气管和主支气管）产生浓度依赖性（1纳摩尔 - 0.3微摩尔）收缩。该反应不受河豚毒素（1微摩尔）影响，吲哚美辛（5微摩尔）使其略有减弱，但异丙肾上腺素（1微摩尔）或乙二胺四乙酸（3毫摩尔）可迅速消除该反应。在支气管中，去除（摩擦）上皮可增强对内皮素的反应。气管或支气管对内皮素（0.3微摩尔）的反应不受氯化镍（0.1毫摩尔）或ω - 芋螺毒素（0.1微摩尔）影响，但硝苯地平（1微摩尔）可部分抑制该反应。
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