谷胱甘肽S-转移酶M1和T1缺失对突尼斯人群癫痫风险的影响。
Effects of glutathione S-transferase M1 and T1 deletions on epilepsy risk among a Tunisian population.
作者信息
Chbili Chahra, B'chir Fatma, Ben Fredj Maha, Saguem Bochra-Nourhène, Ben Amor Sana, Ben Ammou Sofiene, Saguem Saad
机构信息
Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia.
Metabolic Biophysics, Professional Toxicology and Applied Environmental Laboratory, Department of Biophysics, Medicine Faculty of Sousse, Sousse University, Sousse 4002, Tunisia; Laboratory of Natural Substances, National Institute of Research and Physical-Chemical Analysis (INRAP), Technopole Sidi Thabet 2020, Tunisia.
出版信息
Epilepsy Res. 2014 Sep;108(7):1168-73. doi: 10.1016/j.eplepsyres.2014.05.009. Epub 2014 May 27.
Glutathione-S-transferases enzymes are involved in the detoxification of several endogenous and exogenous substances. In this present study, we evaluated the effects of two glutathione-S-transferase polymorphisms, (GSTM1 and GSTT1) on epilepsy risk susceptibility in a Tunisian population. These polymorphisms were analyzed in 229 healthy subjects and 98 patients with epilepsy, using a polymerase chain reaction (PCR). Odds ratio (ORs) was used for analyzing results. The study results demonstrated that individuals with the GSTM1 null genotype were at an increased risk of developing epilepsy [OR=3.80, 95% confidence interval (CI) (2.15-4.78)], whereas no significant effects were observed between individuals with GSTT1 null genotype and epilepsy risk [OR=1.15, 95% CI (0.62-2.12)]. These genotyping finding revealed that the absence of GSTM1 activity could be contributor factor for the development of epilepsy disease.
谷胱甘肽-S-转移酶参与多种内源性和外源性物质的解毒过程。在本研究中，我们评估了两种谷胱甘肽-S-转移酶多态性（GSTM1和GSTT1）对突尼斯人群癫痫易感性的影响。采用聚合酶链反应（PCR）对229名健康受试者和98例癫痫患者进行了这些多态性分析。使用优势比（OR）分析结果。研究结果表明，GSTM1基因缺失型个体患癫痫的风险增加[OR=3.80，95%置信区间（CI）（2.15-4.78）]，而GSTT1基因缺失型个体与癫痫风险之间未观察到显著影响[OR=1.15，95%CI（0.62-2.12）]。这些基因分型结果表明，GSTM1活性的缺失可能是癫痫疾病发生的一个促成因素。
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