Menon Biju K, Rao Ramesh D, Abhyankar Amit, Rajan M G Ramakrishna, Basu Sandip
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, Maharashtra, India.
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, Maharashtra, India
J Nucl Med Technol. 2014 Sep;42(3):194-7. doi: 10.2967/jnmt.114.139162. Epub 2014 Jun 26.
The objective of the study was to make a quantitative comparison of 24-h thyroid uptake calculated by γ camera-based and thyroid uptake probe-based methods after administration of a diagnostic (131)I capsule in patients with benign thyroid disorders.
The study group comprised 66 patients, of whom 26 were male (28-67 y old) and 40 female (20-65 y old). These patients had benign thyroid disorders (primarily hyperthyroidism [thyrotoxicosis]), most of whom had been referred for evaluation before radioiodine treatment. (131)I (25 μCi [925 MBq]) was administered, and 24-h thyroid uptake was calculated using a probe-based method and a camera-based method with a medium-energy parallel-hole collimator. The paired t test was used to check the variation in values obtained by these 2 methodologies.
Of the 66 patients included in this study, 45 had clinical thyrotoxicosis and 21 had nonthyrotoxic multinodular goiter. In the group with thyrotoxicosis, neck uptake ranged from 40.13% to 97.1% by the probe-based method and 36.89% to 95.9% by the camera-based method. In the group with clinically nonthyrotoxic goiter, neck uptake ranged from 1.4% to 38.4% by the probe-based method and 0.6% to 34.8% by the camera-based method. Paired t testing was performed on both groups of patients, and P values were less than 0.05, showing good agreement within the 2 groups of data.
The camera-based method is a good substitute for the probe-based method; though not producing identical results, the former could be used to derive useful quantitative information on thyroid function.
本研究的目的是对诊断性服用（131）I胶囊后，采用基于γ相机和基于甲状腺摄取探头的方法计算的24小时甲状腺摄取量进行定量比较，研究对象为患有良性甲状腺疾病的患者。
研究组包括66例患者，其中男性26例（28 - 67岁），女性40例（20 - 65岁）。这些患者患有良性甲状腺疾病（主要为甲状腺功能亢进症[甲状腺毒症]），大多数患者在接受放射性碘治疗前被转诊进行评估。给予（131）I（25μCi [925MBq]），并使用基于探头的方法和带有中能平行孔准直器的基于相机的方法计算24小时甲状腺摄取量。采用配对t检验来检查这两种方法获得的值的差异。
本研究纳入的66例患者中，45例患有临床甲状腺毒症，21例患有非甲状腺毒症性多结节性甲状腺肿。在甲状腺毒症组中，基于探头的方法测得的颈部摄取率为40.13%至97.1%，基于相机的方法测得的颈部摄取率为36.89%至95.9%。在临床非甲状腺毒症性甲状腺肿组中，基于探头的方法测得的颈部摄取率为1.4%至38.4%，基于相机的方法测得的颈部摄取率为0.6%至34.8%。对两组患者均进行了配对t检验，P值均小于0.05，表明两组数据具有良好的一致性。
基于相机的方法是基于探头的方法的良好替代方法；虽然结果不完全相同，但前者可用于获取有关甲状腺功能的有用定量信息。
