Harper Lorie M, Tita Alan, Biggio Joseph R
The Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama.
Am J Perinatol. 2015 Feb;32(3):239-46. doi: 10.1055/s-0034-1383846. Epub 2014 Jun 27.
The objective of this study was to assess the impact of gestational weight gain outside the Institute of Medicine (IOM) recommendations after the diagnosis of gestational diabetes (GDM) on perinatal outcomes.
This was a retrospective cohort study. Women were classified as gestational weight gain (GWG) within, less than, or greater than IOM recommendations for body mass index as calculated by gestational weight gain per week after a diagnosis of GDM. Outcomes assessed were preeclampsia, cesarean delivery, A2 GDM, birth weight, small for gestational age (SGA), large for gestational age (LGA), macrosomia, and preterm delivery. Groups were compared using analysis of variance and chi-square test for trend, as appropriate. Backward stepwise logistic regression was used to adjust for significant confounding factors.
Of 635 subjects, 92 gained within, 175 gained less than, and 368 gained more than IOM recommendations. The risk of cesarean delivery and A2 GDM was increased in those gaining above the IOM recommendations compared with within. For every 1-lb/week increase in weight gain after diagnosis of GDM, there was a 36 to 83% increase in the risk of preeclampsia, cesarean delivery, A2 GDM, macrosomia, and LGA, without decreases in SGA or preterm delivery.
Weight gain more than the IOM recommendations per week of gestation after a diagnosis of GDM is associated with adverse pregnancy outcomes.
本研究的目的是评估妊娠期糖尿病(GDM)诊断后,孕期体重增加超出医学研究所(IOM)建议范围对围产期结局的影响。
这是一项回顾性队列研究。根据GDM诊断后每周的体重增加情况计算体重指数,将女性分为孕期体重增加(GWG)在IOM建议范围内、低于IOM建议范围或高于IOM建议范围。评估的结局包括子痫前期、剖宫产、A2型GDM、出生体重、小于胎龄儿(SGA)、大于胎龄儿(LGA)、巨大儿和早产。根据情况,使用方差分析和趋势卡方检验对各组进行比较。采用向后逐步逻辑回归分析来调整显著的混杂因素。
在635名受试者中,92人体重增加在IOM建议范围内,175人体重增加低于IOM建议范围,368人体重增加高于IOM建议范围。与体重增加在IOM建议范围内的女性相比,体重增加高于IOM建议范围的女性剖宫产和A2型GDM的风险增加。GDM诊断后,每周体重增加每增加1磅,子痫前期、剖宫产、A2型GDM、巨大儿和LGA的风险增加36%至83%,而SGA或早产的风险并未降低。
GDM诊断后,孕期每周体重增加超过IOM建议范围与不良妊娠结局相关。