Espahbod Camelia, Veitz-Keenan Analia
NYU College of Dentistry, New York, USA.
Evid Based Dent. 2014 Jun;15(2):63. doi: 10.1038/sj.ebd.6401033.
Medline, Embase and the reference lists of identified articles were also scanned for relevant papers.
Only randomised controlled trials in English were considered.
Two reviewers extracted data independently and study quality was assessed using the Jadad score. Meta-analysis was conducted.
Four RCTs with a total of 183 patients were included. Intraoperative blood loss in the tranexamic acid group was statistically reduced (weighted mean difference [WMD] = -93.56, 95% CI = -132.59-54.52, P < .00001). No statistical difference was seen in the postoperative levels of haemoglobin and haematocrit (WMD = 0.50, 95% CIs = -0.43-1.43, P = .29 and WMD = 0.18, 95% CIs = -1.64-1.99, P = .85, respectively).
This meta-analysis confirms that tranexamic acid can effectively reduce intraoperative blood loss in orthognathic surgery, especially by intravenous administration. But tranexamic acid cannot affect postoperative levels of haemoglobin and haematocrit.
