Rausell Antonio, Telenti Amalio
Institute of Microbiology, University Hospital, University of Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Institute of Microbiology, University Hospital, University of Lausanne, Switzerland.
Curr Opin Immunol. 2014 Oct;30:32-8. doi: 10.1016/j.coi.2014.06.001. Epub 2014 Jun 24.
The study of immunity against infection can be framed in the context of genomics. First, long-term association with pathogens results in genomic signatures that result from positive selection. Evolutionary pressures tailor species or individual responses to pathogens, that may be associated with skewed patterns of immunity. Second, recent human population expansion carries an increasing burden of genetic mutation that can result in sporadic immunodeficiencies, and more generally, in diversity in susceptibility to infection. This review highlights current concepts and tools for the analysis of genomes and stresses the interest of these approaches in immunity.
对感染免疫的研究可以在基因组学的背景下进行阐述。首先，与病原体的长期关联会产生由正向选择导致的基因组特征。进化压力塑造了物种或个体对病原体的反应，这可能与免疫模式的偏差有关。其次，近期人类人口的扩张带来了越来越多的基因突变负担，这可能导致散发性免疫缺陷，更普遍地说，会导致对感染易感性的差异。本综述重点介绍了当前用于基因组分析的概念和工具，并强调了这些方法在免疫研究中的重要性。
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