Dodson W C
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.
J Reprod Med. 1989 Jan;34(1 Suppl):76-80.
The use of exogenous gonadotropins for ovulation induction in anovulatory women or for superovulation in gamete intrafallopian transfer or in vitro fertilization is complicated by premature luteinization, multiple gestation and ovarian hyperstimulation. Desensitization of the pituitary gonadotrophs can be achieved with gonadotropin releasing hormone (GnRH) agonists. The adjunctive use of GnRH agonists with exogenous gonadotropins prevents premature luteinization, possibly resulting in an improvement in ovarian stimulation.
对于无排卵女性使用外源性促性腺激素进行排卵诱导，或在配子输卵管内移植或体外受精中进行超排卵时，会因过早黄素化、多胎妊娠和卵巢过度刺激而变得复杂。促性腺激素释放激素（GnRH）激动剂可使垂体促性腺细胞脱敏。GnRH激动剂与外源性促性腺激素联合使用可防止过早黄素化，可能会改善卵巢刺激效果。
