阻塞性睡眠呼吸暂停与深静脉血栓形成/肺栓塞之间的关联：一项基于人群的回顾性队列研究。
Association between obstructive sleep apnea and deep vein thrombosis / pulmonary embolism: a population-based retrospective cohort study.
作者信息
Peng Yi-Hao, Liao Wei-Chih, Chung Wei-Sheng, Muo Chih-Hsin, Chu Chia-Chen, Liu Chin-Jung, Kao Chia-Hung
机构信息
Department of Respiratory Therapy, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan.
China Medical University, Taichung, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
出版信息
Thromb Res. 2014 Aug;134(2):340-5. doi: 10.1016/j.thromres.2014.06.009. Epub 2014 Jun 12.
BACKGROUND
Obstructive sleep apnea (OSA) is a major contributor to cardiovascular disease, and may cause severe morbidity and mortality. Recent studies have indicated that OSA patients exhibited elevated platelet activity, fibrinogen levels, and platelet aggregation.
OBJECTIVES
We investigated the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients diagnosed with OSA compared with age- and sex-matched unaffected people.
PATIENTS/METHODS: This longitudinal, nationwide, population-based cohort study was conducted using data from Taiwan National Health Insurance Research Database (NHIRD) recorded between January 2000 and December 2011. The study consisted of 3511 patients with OSA and 35110 matched comparison individuals. A Cox proportional hazard regression was used to compute the risk of DVT and PE in patients with OSA compared with those without OSA.
RESULTS
The DVT and PE risks were 3.50- and 3.97-fold higher (95% CI=1.83-6.69 and 1.85-8.51) respectively, in the OSA cohort than in the reference cohort after we adjusted for age, sex, and comorbidities.
CONCLUSION
This nationwide population-based cohort study indicates that patients with OSA exhibit a higher risk of subsequent DVT and PE.
背景
阻塞性睡眠呼吸暂停（OSA）是心血管疾病的主要促成因素，可能导致严重的发病率和死亡率。最近的研究表明，OSA患者表现出血小板活性升高、纤维蛋白原水平升高和血小板聚集。
目的
我们调查了与年龄和性别匹配的未受影响人群相比，被诊断为OSA的患者发生深静脉血栓形成（DVT）和肺栓塞（PE）的风险。
患者/方法：这项纵向、全国性、基于人群的队列研究使用了台湾国民健康保险研究数据库（NHIRD）在2000年1月至2011年12月期间记录的数据。该研究包括3511名OSA患者和35110名匹配的对照个体。使用Cox比例风险回归来计算OSA患者与非OSA患者相比发生DVT和PE的风险。
结果
在我们调整了年龄、性别和合并症后，OSA队列中DVT和PE的风险分别比参考队列高3.50倍和3.97倍（95%CI=1.83-6.69和1.85-8.51）。
结论
这项全国性基于人群的队列研究表明，OSA患者发生后续DVT和PE的风险更高。
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