Yi Hai-zhen, Chen Jin-jing, Cen Hong, Yan Wei, Tan Xiao-hong
Department of Medical Oncology, Guangxi Guigang People's Hospital, Guigang, China.
Med Oncol. 2014 Aug;31(8):84. doi: 10.1007/s12032-014-0084-7. Epub 2014 Jun 28.
Whether an association between hepatitis B virus (HBV) infection and B-cell non-Hodgkin's lymphoma (B-NHL) risk exists is an open question. In order to provide quantification of the issue, we carried out a meta-analysis of the published data. We identified 4 case-control and 2 nested case-control studies, including a total of 5,396 B-NHL cases. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates. The odds radio (OR) of HBV infection in B-NHL when compared with the control population was 2.98 [95 % confidence interval (CI) 2.30-3.86]. There was evidence of statistical heterogeneity among all included studies (I (2) = 65 %, P = 0.01), which disappeared in the subgroup nested case-control studies (I (2) = 0 %, P = 0.49). OR was 2.59 (95 % CI 2.03-3.30) in the random effect model, suggesting a higher prevalence of HBV carrier state in B-NHL than controls. This meta-analysis provides quantitative evidence of a favorable role of HBV infection on B-NHL risk, which needs to be confirmed by experimental and epidemiological studies.
乙型肝炎病毒（HBV）感染与B细胞非霍奇金淋巴瘤（B-NHL）风险之间是否存在关联仍是一个悬而未决的问题。为了对该问题进行量化，我们对已发表的数据进行了荟萃分析。我们确定了4项病例对照研究和2项巢式病例对照研究，共纳入5396例B-NHL病例。我们使用随机效应模型得出荟萃分析估计值，并考虑了估计值之间的相关性。与对照人群相比，B-NHL中HBV感染的比值比（OR）为2.98 [95%置信区间（CI）2.30 - 3.86]。所有纳入研究之间存在统计学异质性的证据（I² = 65%，P = 0.01），而在巢式病例对照研究亚组中这种异质性消失了（I² = 0%，P = 0.49）。随机效应模型中的OR为2.59（95% CI 2.03 - 3.30），表明B-NHL中HBV携带者状态的患病率高于对照组。这项荟萃分析提供了定量证据，表明HBV感染对B-NHL风险具有正向作用，这需要通过实验和流行病学研究来证实。
