对艾滋病高危人群血清中与主要核心蛋白（p24）相关的HIV抗原的检测。

Detection of serum HIV-Ag related to the major core protein (p24) in persons at risk for AIDS.

作者信息

Borghi V, De Rienzo B, Pietrosemoli P, Pecorari M, Mongiardo N, Pellegrino F, Zanchetta G P, Lami G, Squadrini F

机构信息

Department of Infectious Diseases, University of Modena, Italy.

出版信息

Microbiologica. 1989 Jan;12(1):81-3.

PMID:2497304

Abstract

A commercial enzyme immunoassay was utilized for the detection of the human immunodeficiency virus antigen (p24) in serum samples from persons at risk for AIDS. The test demonstrated sensitivity to 20 pg/ml of serum antigen. The results obtained showed 14.63% of the subjects (Ss) with persistent generalized lymphadenopathy or asymptomatic Ss, and 69.23% of the Ss with AIDS related complex (ARC) or AIDS to be positive for HIV-Ag. In addition, there were no false-positives in the control serum samples collected from seronegative individual. The close correlation observed between HIV-Ag presence and advanced stages of the disease, stresses the diagnostic importance of this viral marker and its usefulness in the follow-up of Ss with HIV infection.

摘要

采用一种商业酶免疫测定法检测艾滋病高危人群血清样本中的人类免疫缺陷病毒抗原（p24）。该检测对血清抗原的敏感度为20 pg/ml。所得结果显示，14.63%患有持续性全身性淋巴结病的受试者或无症状受试者，以及69.23%患有艾滋病相关综合征（ARC）或艾滋病的受试者HIV抗原呈阳性。此外，从血清阴性个体采集的对照血清样本中没有假阳性。观察到HIV抗原的存在与疾病晚期密切相关，这突出了这种病毒标志物的诊断重要性及其在HIV感染受试者随访中的作用。