Brühwiler J, Lüthy R, Joller-Jemelka H I, Ledergerber B, Fierz W, Siegenthaler W, Grob P J
Abteilung für Infektionskrankheiten, Departement für Innere Medizin, Universitätsspital Zürich.
Dtsch Med Wochenschr. 1989 Jun 30;114(26):1015-20. doi: 10.1055/s-2008-1066709.
Since 1983 the morbidity and mortality rates as well as results of haematological, immunological and (later) HIV serological tests were recorded prospectively for 497 HIV-positive patients during 1837 clinic visits at least twice within at most six months for a median period of observation of 18 months (range 6-64 months). The rate of progression to a higher stage was calculated according to the method of Kaplan-Meier. The rate for asymptomatic patients was 16% after one and 33% after two years; for patients with persisting generalized lymphadenopathy it was 13% and 21%, respectively, for those with AIDS-related complex 28% and 47%, respectively, and for those with AIDS 33% and 82%, respectively. As for results of laboratory tests, patients with progressive disease had significantly lower titres of anti-HIV nuclear antibodies, as well as a higher incidence of HIV-p24 antigen. Haemoglobin levels, platelet and lymphocyte counts and number of CD-4-positive lymphocytes were significantly lower, Neopterin and beta 2-microglobulins higher (P less than 0.01).
自1983年起，对497名HIV阳性患者进行了前瞻性研究，在最多六个月内至少两次门诊就诊，共1837次，中位观察期为18个月（范围6 - 64个月），记录了发病率、死亡率以及血液学、免疫学和（后来的）HIV血清学检测结果。根据Kaplan-Meier方法计算进展到更高阶段的发生率。无症状患者一年后的发生率为16%，两年后为33%；持续性全身淋巴结肿大患者分别为13%和21%，艾滋病相关综合征患者分别为28%和47%，艾滋病患者分别为33%和82%。至于实验室检测结果，疾病进展患者的抗HIV核抗体滴度显著降低，HIV-p24抗原发生率更高。血红蛋白水平、血小板和淋巴细胞计数以及CD-4阳性淋巴细胞数量显著降低，新蝶呤和β2-微球蛋白升高（P < 0.01）。
