Ohn Mon, Jacobe Stephen
Advanced Trainee in Respiratory Medicine and General Paediatrics, The Children's Hospital at Westmead, Sydney.
Senior Staff Specialist, Paediatric Intensive Care Unit, The Children's Hospital at Westmead, Sydney, and Clinical Associate Professor, Sydney Medical School, University of Sydney.
Paediatr Respir Rev. 2014 Dec;15(4):319-21. doi: 10.1016/j.prrv.2014.05.004. Epub 2014 Jun 5.
Asthma is one of the most prevalent chronic condition affecting children worldwide and acute exacerbations requiring emergency medical management are common. In addition to corticosteroids, a number of drugs may be used in the management of acute severe asthma aiming to reverse bronchoconstriction. Magnesium sulphate - either inhaled or intravenous - may be added to conventional therapy of children with acute severe asthma. Despite its safety profile and effectiveness, the use of magnesium sulphate has been inconsistent due to lack of consensus. The authors believe that the accumulating evidence of a favorable 'cost benefit' profile justifies the use of magnesium for all children presenting with acute severe asthma.
哮喘是全球影响儿童的最常见慢性病之一,需要紧急医疗处理的急性加重情况很常见。除皮质类固醇外,许多药物可用于急性重度哮喘的治疗,旨在逆转支气管收缩。硫酸镁——无论是吸入还是静脉注射——可添加到急性重度哮喘儿童的常规治疗中。尽管硫酸镁具有安全性和有效性,但由于缺乏共识,其使用情况并不一致。作者认为,越来越多关于“成本效益”良好的证据证明,对于所有出现急性重度哮喘的儿童都应使用硫酸镁。