N-多苄基化脂环族1,2-二胺：癌细胞系中的细胞毒性和G1期阻滞
N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.
作者信息
Caldarelli Antonio, De Biasio Valeria, Giovenzana Giovanni B, Mastronardo Gianpiero, Negri Roberto
机构信息
Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro", L.go Donegani 2, I-28100 , Novara NO, Italy.
出版信息
Mol Divers. 2014 Nov;18(4):879-86. doi: 10.1007/s11030-014-9519-5. Epub 2014 Jun 28.
PMID:24973276
Abstract
Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.
摘要
在用N,N,N',N'-四苄基-4,5-二氨基-2-环戊烯酮处理的癌细胞系中观察到了微摩尔范围内的细胞毒性。对HeLa细胞的细胞周期分析显示出明显的G1期阻滞。为了确定药效基团，对结构类似物进行了初步的构效关系研究。
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