Pandey Janardan P, Kistner-Griffin Emily, Radwan Faisal F, Kaur Navtej, Namboodiri Aryan M, Black Laurel, Butler Mary Ann, Carreón Tania, Ruder Avima M
Department of Microbiology and Immunology.
Department of Public Health Sciences, Medical University of South Carolina, Charleston.
J Infect Dis. 2014 Dec 1;210(11):1823-6. doi: 10.1093/infdis/jiu367. Epub 2014 Jun 27.
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; P=.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
人类巨细胞病毒(HCMV)是许多人类疾病的危险因素,但在接触该病毒的个体中,并非每个人感染HCMV引发疾病的可能性都相同,这意味着存在可能调节对该病毒免疫的宿主遗传因素。在此,我们表明,对HCMV糖蛋白B(gB)的抗体反应性与特定的免疫球蛋白GM(γ标记)基因型显著相关。GM 17/17纯合子的抗HCMV gB抗体水平最高,GM 3/17杂合子次之,GM 3/3纯合子最低(分别为28.2、19.0和8.1μg/mL;P = 0.014)。这些发现为HCMV引发疾病的发病机制提供了深入见解。