The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Cell Immunol. 2014 Jul;290(1):116-9. doi: 10.1016/j.cellimm.2014.06.003. Epub 2014 Jun 18.
Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.
贝赫切特病（BD）是一种病因不明的自身免疫性疾病。白细胞介素-28A（IL-28A）促进免疫反应，可能参与自身免疫性疾病的发病机制。为了研究 IL-28A 在 BD 发病机制中的作用，我们测量了 19 例 BD 患者和 16 例健康个体的 IL-28A 刺激外周血单个核细胞（PBMC）中 IFN-γ 和 IL-17 的表达。我们发现 BD 患者和对照组患者的血清中均无法检测到 IFN-γ 和 IL-17。与健康个体相比，BD 患者经 IL-28A 刺激的 PBMC 中 IFN-γ 的 mRNA 表达和蛋白产物显著增加。经 IL-28A 刺激的 PBMC 中 IL-17 的 mRNA 表达和蛋白产物在 BD 患者与正常个体之间无显著差异。
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