Fakurnejad Shayan, Scheer Justin K, Patwardhan Avinash G, Havey Robert M, Voronov Leonard I, Smith Zachary A
Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, 676 N. St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Department of Orthopaedic Surgery, Loyola University, Stritch School of Medicine, Maywood, IL, USA; Musculoskeletal Biomechanics Laboratory, Rehabilitation Research and Development Center, Edward Hines Jr. VA Hospital, Hines, IL, USA.
J Clin Neurosci. 2014 Dec;21(12):2059-64. doi: 10.1016/j.jocn.2014.05.002. Epub 2014 Jun 25.
Much controversy exists regarding the mechanism of burst fracture (BF) induction and the proper techniques to treat such fractures. As such, there is a great need for validated preclinical models in which to study these injuries. In this study, an electronic search of the PubMed database (MEDLINE) was performed and the results were filtered to obtain only studies with a biomechanical focus. Forty five biomechanical studies were obtained, from which four distinct methods of injury induction were identified. Twenty one (46.7%) involved clinically relevant techniques for treating BF, involving anterior, posterior, circumferential, or a combination of approaches. Fifteen (71.4%) of the treatment studies used unstable spine specimens that do not fit the classical characteristics of BF. Given the consistent use of BF models that do not adhere to classical definitions, the clinical value of ex vivo induction is uncertain.
关于爆裂骨折（BF）的诱发机制以及治疗此类骨折的恰当技术存在诸多争议。因此，非常需要经过验证的临床前模型来研究这些损伤。在本研究中，对PubMed数据库（MEDLINE）进行了电子检索，并对结果进行筛选，仅获取侧重于生物力学的研究。共获得45项生物力学研究，从中确定了4种不同的损伤诱发方法。21项研究（46.7%）涉及治疗BF的临床相关技术，包括前路、后路、环形或联合入路。15项治疗研究（71.4%）使用了不符合BF经典特征的不稳定脊柱标本。鉴于一直使用不符合经典定义的BF模型，体外诱发的临床价值尚不确定。
