Wang Jun-Jun, Zhao Rong, Liang Ji-Chao, Chen Yong
Yao Xue Xue Bao. 2014 Apr;49(4):476-81.
The effects of magnolol (Mag) on hyperglycemia and hyperlipemia, hepatic oxidative stress and cytochrome P4502E1 (CYP2E1) activity of diabetic rats induced by high-fat diet (HFD) and streptozotocin (STZ) were studied. After oral administration of Mag (25, 50 and 100 mg x kg(-1) x d(-1)) for continuous 10 weeks, the blood glucose and lipids (TC, TG and LDL-C) levels, as well as the hepatic CYP2E1 activity and MDA content of diabetic rats, decreased significantly (P < 0.05 or P < 0.01), whereas the oral glucose tolerance and hepatic antioxidant enzymatic activities (CAT and GSH-Px) of diabetic rats, increased significantly (P < 0.05 or P < 0.01). The results indicated that Mag was effective against the hepatic oxidative damage, hyperglycemia and hyperlipemia of diabetic rats induced by HFD and STZ, and the inhibition of Mag on hepatic CYP2E1 activity could be an important mechanism of Mag against hepatic insulin resistance and oxidative damage.
研究了厚朴酚（Mag）对高脂饮食（HFD）和链脲佐菌素（STZ）诱导的糖尿病大鼠高血糖、高血脂、肝脏氧化应激及细胞色素P4502E1（CYP2E1）活性的影响。连续10周口服Mag（25、50和100 mg·kg⁻¹·d⁻¹）后，糖尿病大鼠的血糖和血脂（总胆固醇、甘油三酯和低密度脂蛋白胆固醇）水平以及肝脏CYP2E1活性和丙二醛含量显著降低（P < 0.05或P < 0.01），而糖尿病大鼠的口服葡萄糖耐量和肝脏抗氧化酶活性（过氧化氢酶和谷胱甘肽过氧化物酶）显著升高（P < 0.05或P < 0.01）。结果表明，Mag对HFD和STZ诱导的糖尿病大鼠肝脏氧化损伤、高血糖和高血脂有效，Mag对肝脏CYP2E1活性的抑制可能是其对抗肝脏胰岛素抵抗和氧化损伤的重要机制。
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