Department of Zoology, Yashwantrao Chavan Institute of Science, Satara, Maharashtra 415001, India.
Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Int J Mol Sci. 2018 Aug 10;19(8):2362. doi: 10.3390/ijms19082362.
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.
在过去的几十年里，人们进行了广泛的研究来挑战致癌作用；然而，它仍然是最重要的健康关注点之一，具有最差的预后和诊断。越来越多的证据清楚地表明，未来癌症发病率将增加，并将在全球造成严重破坏，将其指定为一种流行病。传统的化疗药物和合成学科的治疗方法通常与不良反应和化疗耐药性的发展有关。因此，有必要发现新的经济实惠且对患者友好的安全有效的药物。迄今为止，已有几种天然化合物被证明对这种可怕的疾病具有潜在的疗效。厚朴酚是从木兰科植物的根和茎皮中分离得到的一种羟基化联苯。厚朴酚能有效地预防或抑制各种癌症的生长，这些癌症起源于不同的器官，如脑、乳腺、宫颈、结肠、肝、肺、前列腺、皮肤等。考虑到这些方面，本综述主要集中讨论厚朴酚对各种类型癌症的作用，以及厚朴酚的来源和化学性质，以及厚朴酚作用靶点的分子机制。本综述提出厚朴酚是一种合适的候选药物，可以进行适当的设计，并开发成为一种有效的抗癌药物。
