Rovenská Eva
Vnitr Lek. 2014 May-Jun;60(5-6):484-9.
Melanoma is highly malignant tumor which arises through malignant transformation of melanocytes. Surgical treatment of primary cutaneous melanoma including radical excision and intervention in regional lymphatic drainage is irreplaceable. Sentinel node biopsy is a recognized method of defining the stage of disease. Performance of sentinel node biopsy in patients in clinical stage Ib and II may reveal clinically occult nodal disease and thereby help identify a group of patients with occult stage III disease who may thereafter undergo complete lymphadenectomy and systemic treatment. Sentinel node biopsy is beneficial in treatment of melanoma, but the therapeutic value of sentinel node biopsy is still not completely clear and remains disputable.
黑色素瘤是一种通过黑素细胞恶性转化产生的高度恶性肿瘤。原发性皮肤黑色素瘤的手术治疗，包括根治性切除和区域淋巴引流干预，是不可替代的。前哨淋巴结活检是确定疾病分期的一种公认方法。对临床Ib期和II期患者进行前哨淋巴结活检可能会发现临床上隐匿的淋巴结疾病，从而有助于识别一组隐匿性III期疾病患者，这些患者此后可能需要接受根治性淋巴结清扫和全身治疗。前哨淋巴结活检对黑色素瘤的治疗有益，但前哨淋巴结活检的治疗价值仍不完全清楚，仍存在争议。
