天然D-葡萄糖作为一种可生物降解的磁共振成像（MRI）弛豫剂。
Natural D-glucose as a biodegradable MRI relaxation agent.
作者信息
Yadav Nirbhay N, Xu Jiadi, Bar-Shir Amnon, Qin Qin, Chan Kannie W Y, Grgac Ksenija, Li Wenbo, McMahon Michael T, van Zijl Peter C M
机构信息
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
出版信息
Magn Reson Med. 2014 Sep;72(3):823-8. doi: 10.1002/mrm.25329. Epub 2014 Jun 27.
PURPOSE
Demonstrate applicability of natural D-glucose as a T2 MRI contrast agent.
METHODS
D-glucose solutions were prepared at multiple concentrations and variable pH. The relaxation rate (R2 = 1/T2 ) was measured at 3, 7, and 11.7 T. Additional experiments were performed on blood at 11.7 T. Also, a mouse was infused with D-glucose (3.0 mmol/kg) and dynamic T2 weighted images of the abdomen acquired.
RESULTS
The transverse relaxation rate depended strongly on glucose concentration and solution pH. A maximum change in R2 was observed around physiological pH (pH 6.8-7.8). The transverse relaxivities at 22°C (pH 7.3) were 0.021, 0.060, and 0.077 s(-1) mM(-1) at 3.0, 7.0, and 11.7 T, respectively. These values showed good agreement with expected values from the Swift-Connick equation. There was no significant dependence on glucose concentration or pH for T1 and the diffusion coefficient for these solutions. The transverse relaxivity in blood at 11.7 T was 0.09 s(-1) mM(-1) . The dynamic in vivo experiment showed a 10% drop in signal intensity after glucose infusion followed by recovery of the signal intensity after about 50-100 s.
CONCLUSION
Glucose can be used as a T2 contrast agent for MRI at concentrations that are already approved for human use.
目的
证明天然D-葡萄糖作为T2磁共振成像（MRI）造影剂的适用性。
方法
制备了多种浓度和不同pH值的D-葡萄糖溶液。在3、7和11.7特斯拉下测量弛豫率（R2 = 1/T2）。在11.7特斯拉下对血液进行了额外实验。此外，给一只小鼠注入D-葡萄糖（3.0 mmol/kg）并采集腹部的动态T2加权图像。
结果
横向弛豫率强烈依赖于葡萄糖浓度和溶液pH值。在生理pH值（pH 6.8 - 7.8）附近观察到R2的最大变化。在22°C（pH 7.3）时，3.0、7.0和11.7特斯拉下的横向弛豫率分别为0.021、0.060和0.077 s(-1) mM(-1)。这些值与Swift-Connick方程的预期值显示出良好的一致性。对于这些溶液，T1和扩散系数对葡萄糖浓度或pH值没有显著依赖性。在11.7特斯拉下血液中的横向弛豫率为0.09 s(-1) mM(-1)。动态体内实验显示，注入葡萄糖后信号强度下降10%，随后在约50 - 100秒后信号强度恢复。
结论
葡萄糖可以在已被批准用于人体的浓度下用作MRI的T2造影剂。
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