Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.
Small. 2014 Oct 29;10(20):4130-5. doi: 10.1002/smll.201303921. Epub 2014 Jun 26.
Novel cationic molecules based on rigid terephthalamide-bisurea cores flanked by imidazolium moieties are described. In aqueous media, these compounds self-assemble into supramolecular nanostructures with distinct morphologies. The compound with optimal hydrophilic/hydrophobic balance displays potent antimicrobial activity and high selectivity towards clinically-isolated MRSA without inducing drug-resistance. These self-assembled cationic antimicrobial nanostructures show promise for the prevention and treatment of multidrug-resistant infections.
本文描述了一类新型的基于刚性对苯二甲酰胺-双脲核心并带有咪唑基团的阳离子分子。在水介质中，这些化合物自组装成具有独特形态的超分子纳米结构。具有最佳亲水/疏水平衡的化合物表现出强大的抗菌活性和对临床分离的耐甲氧西林金黄色葡萄球菌（MRSA）的高选择性，而不会诱导耐药性。这些自组装的阳离子抗菌纳米结构有望用于预防和治疗多重耐药感染。
