McLeod B C, Sassetti R J, Owens E A, Scott J P
Rush Medical Center, Chicago, Illinois.
Transfusion. 1989 May;29(4):332-6. doi: 10.1046/j.1537-2995.1989.29489242800.x.
To increase cost efficiency, the simultaneous collection of platelets during plasma-exchange donation of cryoprecipitate was investigated. Sixteen desmopressin (DDAVP)-stimulated donors underwent 90 simultaneous donations. Permanent donor plasma loss for each donation averaged 150 ml in cryoprecipitate and 151 ml in platelet concentrates. Mean factor VIII (FVIII) yield was 4699 +/- 2754 IU per donation. The mean yield in the platelet products was 4.63 X 10(11) platelets; aggregation properties and posttransfusion increments were satisfactory. White cell contamination averaged 4.05 X 10(9) but could be lowered by a secondary centrifugation. The direct cost for a single-donor platelet transfusion produced in this way is estimated at $102.19 and that for FVIII at $0.055 per IU. Simultaneous donation is technically feasible and safe for donors, and it provides functional products that are more cost-effective than apheresis platelets or cryoprecipitate donated separately.
为提高成本效益，对在冷沉淀血浆置换捐献过程中同时采集血小板进行了研究。16名去氨加压素（DDAVP）刺激的捐献者进行了90次同步捐献。每次捐献的永久性供体血浆损失在冷沉淀中平均为150毫升，在血小板浓缩物中平均为151毫升。每次捐献的平均凝血因子VIII（FVIII）产量为4699 +/- 2754国际单位。血小板制品的平均产量为4.63×10¹¹个血小板；聚集特性和输血后增量令人满意。白细胞污染平均为4.05×10⁹个，但可通过二次离心降低。以这种方式生产的单供体血小板输血的直接成本估计为102.19美元，FVIII的成本为每国际单位0.055美元。同步捐献在技术上对捐献者是可行且安全的，并且它提供了比单采血小板或单独捐献的冷沉淀更具成本效益的功能性产品。
