Suzuki Ayana, Hirokawa Mitsuyoshi, Higuchi Miyoko, Yamao Naoki, Kuma Seiji, Nakamura Hirotoshi, Amino Nobuyuki, Miyauchi Akira
Department of Laboratory, Kuma Hospital, Kobe, Hyogo, Japan.
Diagn Cytopathol. 2015 Feb;43(2):108-13. doi: 10.1002/dc.23191. Epub 2014 Jun 28.
The cytological findings in conventional specimens (C-S) and liquid-based cytology specimens (LBC-S) are not quite same. The aim of this article is to clarify the cytological findings of papillary thyroid carcinoma (PTC) characteristic of LBC-S.
Out of 5,971 cases diagnosed in a single institution from March to September in 2012, 161 PTC cases with both C-S and LBC-S were reviewed. Additionally, we compared the findings with those in LBC-S of 55 adenomatous or hyperplastic nodule (AN) and 21 follicular neoplasm (FN) cases.
Compared to C-S, the incidences of trabecular and hobnail patterns, collagenous stroma, naked capillaries, intercellular spaces, convoluted nuclei, eosinophilic nucleoli, and perinucleolar halo were increased. Pale nuclei were observed in only one of 161 PTC cases. Specificity of convoluted nuclei and perinucleolar halo were 97.4% and 96.1%, respectively.
Convoluted nuclei and perinucleolar halo might become a new indicator of PTC in LBC-S. Contrarily, we should be aware that pale nuclei are rarely observed in LBC-S.
传统标本（C-S）和液基细胞学标本（LBC-S）中的细胞学发现并不完全相同。本文旨在阐明LBC-S中甲状腺乳头状癌（PTC）的细胞学发现特征。
回顾了2012年3月至9月在单一机构诊断的5971例病例中的161例同时有C-S和LBC-S的PTC病例。此外，我们将这些发现与55例腺瘤性或增生性结节（AN）和21例滤泡性肿瘤（FN）病例的LBC-S发现进行了比较。
与C-S相比，小梁状和鞋钉样模式、胶原性间质、裸露毛细血管、细胞间隙、核卷曲、嗜酸性核仁及核仁周围晕的发生率增加。161例PTC病例中仅1例观察到淡染核。核卷曲和核仁周围晕的特异性分别为97.4%和96.1%。
核卷曲和核仁周围晕可能成为LBC-S中PTC的新指标。相反，我们应该意识到在LBC-S中很少观察到淡染核。
