NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels.
作者信息
Pillozzi Serena, Gasparoli Luca, Stefanini Matteo, Ristori Mirco, D'Amico Massimo, Alessio Enzo, Scaletti Federica, Becchetti Andrea, Arcangeli Annarosa, Messori Luigi
机构信息
Department of Experimental and Clinical Medicine, University of Florence, Viale GB Morgagni 50, 50134 Firenze, Italy.
出版信息
Dalton Trans. 2014 Aug 28;43(32):12150-5. doi: 10.1039/c4dt01356e.
We report here that the established anticancer ruthenium(iii) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.
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