Haykowsky Mark J, Kitzman Dalane W
Faculty of Rehabilitation Medicine, Alberta Cardiovascular and Stroke Research Centre (ABACUS), Mazankowski Alberta Heart Institute, University of Alberta, 3-16 Corbett Hall, Edmonton, Alberta T6G-2G4, Canada.
Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USA.
Heart Fail Clin. 2014 Jul;10(3):445-52. doi: 10.1016/j.hfc.2014.04.001. Epub 2014 May 22.
Recent advances in the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFPEF) suggest that noncardiac peripheral factors contribute to the reduced peak V(o2) (peak exercise oxygen uptake) and to its improvement after endurance exercise training. A greater understanding of the peripheral skeletal muscle vascular adaptations that occur with physical conditioning may allow for tailored exercise rehabilitation programs. The identification of specific mechanisms that improve whole body and peripheral skeletal muscle oxygen uptake could establish potential therapeutic targets for medical therapies and a means to follow therapeutic response.
射血分数保留的心力衰竭（HFpEF）患者运动不耐受病理生理学的最新进展表明，非心脏外周因素导致峰值V（o2）（峰值运动摄氧量）降低以及耐力运动训练后其改善。对体育锻炼时外周骨骼肌血管适应性的更深入了解可能有助于制定个性化的运动康复计划。确定改善全身和外周骨骼肌摄氧量的具体机制可以为药物治疗确立潜在的治疗靶点，并提供一种跟踪治疗反应的方法。
