Yamaguchi Toru
Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Clin Calcium. 2014 Jul;24(7):21-6.
In lifestyle-related common diseases, Diabetes mellitus is known to cause not only atherosclerosis and cardiovascular events but also bone fragility and high fracture risk. Advanced glycation endproducts (AGEs), which are deeply involved in diabetes pathogenesis, experimentally induce the calcification of aortic smooth muscle, while suppressing the osteoblastic differentiation and calcification of marrow stromal cells. AGEs also clinically and adversely affect fracture risk in diabetic patients. In contrast, bone deterioration is positively linked to the aggravation of lifestyle-related common diseases by diminishing in osteoblast-specific osteoclacin and Wnt signal, which increases blood glucose and triglyceride levels, and aggravates atherosclerosis.
在与生活方式相关的常见疾病中，糖尿病不仅会引发动脉粥样硬化和心血管事件，还会导致骨质脆弱和高骨折风险。晚期糖基化终产物（AGEs）与糖尿病发病机制密切相关，实验表明它会诱导主动脉平滑肌钙化，同时抑制骨髓基质细胞的成骨细胞分化和钙化。AGEs在临床上也会对糖尿病患者的骨折风险产生不利影响。相比之下，骨退化通过减少成骨细胞特异性骨钙素和Wnt信号，与生活方式相关常见疾病的加重呈正相关，这会增加血糖和甘油三酯水平，并加重动脉粥样硬化。
