含多种二酮哌嗪单元的类肽寡聚物的固相合成。
Solid-phase synthesis of peptoid-like oligomers containing diverse diketopiperazine units.
作者信息
Suwal Sujit, Kodadek Thomas
机构信息
Department of Chemistry and Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
出版信息
Org Biomol Chem. 2014 Aug 21;12(31):5831-4. doi: 10.1039/c4ob00829d.
Abstract
Diketopiperazine (DKP) units are found in many bioactive small molecules. Here we report facile chemistry for incorporating diverse DKP units within peptoid and peptoid-like libraries made by solid-phase split and pool synthesis.
摘要
二酮哌嗪（DKP）单元存在于许多生物活性小分子中。在此，我们报道了一种简便的化学方法，可将多种DKP单元引入通过固相拆分和混合合成制备的类肽和类肽样文库中。
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