Chen Dezhi, Guo Xiaoyan, Zheng Zhenzhen, Wei Qianqian, Song Wei, Cao Bei, Huang Rui, Yang Rong, Shang Huifang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Muscle Nerve. 2015 Mar;51(3):353-7. doi: 10.1002/mus.24325. Epub 2015 Jan 6.
Depression and anxiety are common in amyotrophic lateral sclerosis (ALS) patients and caregivers.
In this study we investigated 93 ALS patients and their 93 caregivers. Depression and anxiety were quantified by the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, respectively.
Very strong correlations between depression and anxiety were found among patients and their caregivers. The severity of depression and anxiety of patients correlated moderately with that of their caregivers. No correlations were found between the severity of depression and anxiety and ALS Functional Rating Scale-Revised (ALSFRS-R) score or for disease duration among patients and caregivers. However, severity of depression and anxiety in caregivers correlated with their age.
Depression and anxiety in ALS patients and their caregivers were associated closely with each other but not with physical disability or disease duration in our Chinese population.
抑郁症和焦虑症在肌萎缩侧索硬化症（ALS）患者及其照料者中很常见。
在本研究中，我们调查了93例ALS患者及其93名照料者。分别采用汉密尔顿抑郁量表和汉密尔顿焦虑量表对抑郁和焦虑进行量化。
在患者及其照料者中发现抑郁与焦虑之间存在非常强的相关性。患者抑郁和焦虑的严重程度与照料者的抑郁和焦虑严重程度呈中度相关。在患者及其照料者中，抑郁和焦虑的严重程度与ALS功能评定量表修订版（ALSFRS-R）评分或病程之间均未发现相关性。然而，照料者的抑郁和焦虑严重程度与他们的年龄相关。
在我们的中国人群中，ALS患者及其照料者的抑郁和焦虑彼此密切相关，但与身体残疾或病程无关。
