Cavaletti Guido
Experimental Neurology Unit and Milan Center for Neuroscience, Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy.
J Peripher Nerv Syst. 2014 Jun;19(2):66-76. doi: 10.1111/jns5.12073.
Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent and severe long-term side effects of cancer chemotherapy. Preclinical and clinical studies have extensively investigated CIPN searching for effective strategies to limit its severity or to treat CIPN-related impairment, but the results have been disappointing. Among the reasons for this failure are methodological flaws in both preclinical and clinical investigations. Their successful resolution might provide a brighter perspective for future studies. Among the several neurotoxic chemotherapy drugs, oxaliplatin may offer a clear example of a methodological approach eventually leading to successful clinical trials. However, the same considerations apply to the other neurotoxic agents and, although frequently neglected, also to the new "targeted" agents.
化疗引起的周围神经毒性（CIPN）是癌症化疗最常见且严重的长期副作用之一。临床前和临床研究广泛探究了CIPN，以寻找有效策略来减轻其严重程度或治疗与CIPN相关的损伤，但结果令人失望。造成这种失败的原因包括临床前和临床研究中的方法缺陷。成功解决这些问题可能为未来研究提供更光明的前景。在几种具有神经毒性的化疗药物中，奥沙利铂可能是最终导致临床试验成功的方法学途径的一个明显例子。然而，同样的考虑也适用于其他神经毒性药物，并且尽管常常被忽视，但也适用于新的“靶向”药物。
